Familial Breast Cancer Risk Continues Throughout a Woman's Life
- From: biospace <biospace@xxxxxxxxxxxxx>
- Date: Sun, 25 Jan 2009 21:58:34 -0800 (PST)
Women who have a sister diagnosed with breast cancer are at an
increased risk of developing the disease throughout their lives. The
increased risk is most pronounced in younger women, regardless of the
age at which the first sister was diagnosed.
Women who have a first degree relative affected by breast cancer are
at increased risk for the disease, but it is unclear how a woman's
risk varies with her current age and the age at which her relative was
diagnosed.
To find out, Marie Reilly, Ph.D., and colleagues at the Karolinska
Institute in Stockholm analyzed a national family database that is
linked to the national cancer register. They compared the breast
cancer incidence between 1958 and 2001 in 23,654 sisters of breast
cancer patients and in 1,732,775 women who did not have a sister with
breast cancer.
The familial risk was highest for young women, aged 20 to 39, with a
6.6-fold increase in the risk of breast cancer diagnosis, compared
with similarly aged women who did not have a sister with breast
cancer. The excess risk declined to approximately two-fold for women
aged 50 and older. For the sisters of a breast cancer patient, the
risk of diagnosis was similar regardless of whether she was
approaching the age at which her sister had been diagnosed or had
already passed it.
Tonny
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