Re: Aspirin cuts stomach cancer risk


"Ed Friedman" <ed@xxxxxxxxxxxxxxxxx> wrote in message
news:nRikl.2$D%7.1@xxxxxxxxxxxxxxxxxxxx


James Howard wrote:
Well, the influence of testosterone in breast cancer has / is being
considered causative by itself, not being converted to estradiol. For
example: ".testosterone might be more strongly associated with [breast
cancer] risk [in women] than estradiol." (Journal of the National Cancer
Institute 2002; 94: 606-616). Since then other reports are suggesting
the same: "CONCLUSIONS: This study provides further evidence that high
levels of circulating testosterone increase the risk of developing breast
cancer in postmenopausal women. The cancers that develop are mainly
estrogen receptor positive. Although HER2(+) and HER2(-) breast cancers
were both associated with high total testosterone, they showed opposing
associations with estrogen." Cancer Epidemiol Biomarkers Prev. 2009
Jan;18(1):169-76


I'm afraid that you are missing my point here. Serum levels of estradiol
are not a risk factor for breast cancer, but rather high local levels of
estradiol are what starts up breast cancer. E.g., in post-menopausal
women the level of estradiol at the breast cancer site is typically as
much as 20 times greater than the serum level of estradiol.

The conclusions drawn by the researchers in the papers you cite are pretty
much meaningless because they are just making guesses since they don't
truly understand the underlying biochemistry. You can only refer to their
results if you wish to argue your case. Needless to say, women in their
late teens and early twenties have the highest amounts of testosterone,
and if your model were correct then you would expect to see the maximum
rate of breast cancer in women in their late twenties and early thirties,
assuming a 10 year lag from the first cancer cell until the time of
detection. Of course, all of the other hormones are also protective
against breast cancer for women with normal genetics, which also explains
the lower breast cancer rate in younger women.

Ed Friedman

Well, earlier I pointed out that I think low DHEA is involved in breast
cancer / all cancers. DHEA naturally begins to decline around age twenty,
reaching very low levels in old age. This is why I think most cancers occur
in old age, including breast cancer and why the high testosterone in young
women does not trigger a high incidence. The ratio of DHEA to testosterone
is not conducive to cancer in young women. However, it probably does start
the process which manifests in old age. However, since you appear to know
better, then I guess I will just have to wait to see if my ideas are
supported.


.

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