Iron low-load can mitigate severity of liver injury

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Date: 03/28/05 

Date: 27 Mar 2005 19:35:38 -0800

Wei Sheng Yan Jiu. 2004 Nov;33(6):687-9. Related Articles, Links

[Putative mechanism of experimental immunological liver injury and
influence of iron low-load on the injury in rat]

[Article in Chinese]

Zhuang J, Wang Z, Liu J, Gou L.

Bethune Medical College, Shijiazhuang 050081, China.

OBJECTIVE: To investigate the effects of superoxide dismutase (SOD) and
reducing iron load on experimental immunological liver injury in rat.
METHODS: 48 male Wistar rats were divided into six groups randomly. The
animal model of iron low-load was created by intravenation of
deferoxamine (DFO) or phlebotomy respectively. Immunological liver
damage model was reproduced by injection of lipopolysaccharide (LPS)
and BCG (Bacilli Calmette Guerin). The following parameters were
determined such as serum iron (SI), transferrin (TRF) concentration,
total proteins (TP) volume, the serum activities of asparatate
aminotransferase (AST), and malondialdehyde (MDA) content, the
activities of superoxide dismutase and iron deposition (HIC) in liver
tissue extracts. RESULTS: In comparison with blank control group, the
SI levels lowered (P < 0.05) in pure DFO group, pure phlebotomy group
and liver injury group. Compared with each own control groups, the
serum activities of AST in all injury groups augmented and the levels
of TP in them reduced significantly. The increased magnitude of the
activities of AST and the decreased magnitude of TP levels in DFO
injury group and phlebotomy injury group were less than those of pure
injury group (P < 0.05). In comparison with the control group, the MDA
levels in pure DFO and phlebotomy groups declined significantly and the
activities of SOD in them had no significant difference. Compared with
each own control groups, the MDA levels augmented and the activities of
SOD reduced significantly in all injury groups. CONCLUSION: SOD
activity reduces in immunological liver injury in rat. Iron low-load
can mitigate the severity of liver injury.

PMID: 15727178 [PubMed - in process]

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