Re: Protective niche for Borrelia burgdorferi to evade humoral immunity.

From: Phyllis Mervine (pmerv_at_direcway.com)
Date: 09/29/04 

Date: 29 Sep 2004 16:06:30 -0700

GregGerber@hotmail.com (Greg Gerber) wrote in message news:<146041df.0409290726.72cefafe@posting.google.com>...
--b burgdorferi
> is proven to be intracellular in vitro but never in vivo.

Borrelia burgdorferi recovered from infected mammal cells

In the March 2001 issue of Infection and Immunity Dorward and Larson
demonstrate that Bb spirochetes can adhere to mouse lymphocytes and
that Bb spirochetes with affinity for mouse lymphocytes can establish
disseminated infections in mice. This was the first study to
demonstrate the attraction of Bb to mammalian lymphocytes in vivo.
 
The recovery of viable spirochetes in this study from mouse B and T
cells indicates that the spirochetes and the lymphocytic cells are in
intimate contact with one another in the mammal. While previous work
demonstrated that Bb spirochetes could target, adhere to, and invade
primary human B and T lymphocytes in vitro, the exact nature of the in
vivo spirochete-lymphocytes interactions could not be demonstrated by
electron microscopy in this study; the same lymphocyte preparations
from the spleen and blood of infected mice did however produce active
spirochetal cultures.

The authors speculate that visualization may not have been possible
due to a low number of spirochetes per ml. This study supports the
suggestion that cellular tropism and lymphocytic-Bb interactions may
be mechanisms of persistent infection and disease pathogenesis in the
mammalian host.

Phyllis Mervine, President
California Lyme Disease Association
Affiliate of the Lyme Disease Association, Inc.
PO Box 1423
Ukiah, CA 95482

Check our websites at calda.intranets.com,
www.lymedisease.org and www.lymetimes.org

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