Medline Abstracts on Silver: NOT SAFE NOT EFFECTIVE NOT APPROVED! BEWARE OF BRENT'S LIES!
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Date: 01/29/05
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Date: 29 Jan 2005 07:50:56 -0800
J Wound Care. 2004 Apr;13(4):154-5. Related Articles, Links
Colloidal silver as an antimicrobial agent: fact or fiction?
van Hasselt P, Gashe BA, Ahmad J.
Ear Clinic, Bamalete Lutheran Hospital, Ramotswa, Botswana.
pvhasselt@planet.nl
OBJECTIVE: Colloidal silver preparations are marketed on the internet
as omnipotent antimicrobial agents, but scientific support for these
claims is lacking. This study reports the results of in vitro tests of
colloidal silver's antimicrobial activity against several pathogenic or
non-pathogenic microorganisms. METHOD: Three samples of colloidal
silver were tested: one available commercially on the internet (silver
concentration of 22 ppm) and two samples (concentrations of 403 and 413
ppm) which were prepared in our laboratory using standard chemical
methods. RESULTS: In an agar-well diffusion assay none of the three
colloidal silver solutions had any effect on the growth of the test
organisms. All tested bacterial strains were sensitive to
ciprofloxacin. Colloidal silver 22 ppm showed no bactericidal activity
in phenol coefficient tests. CONCLUSION: As the tested colloidal silver
solutions did not show any antimicrobial effect in vitro on the
microorganisms, claims of colloidal silver's antimicrobial potency are
misleading and there is no place for it as an antiseptic.
Publication Types:
Evaluation Studies
PMID: 15114827 [PubMed - indexed for MEDLINE]
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Neurology. 2004 Apr 27;62(8):1408-10. Related Articles, Links
Myoclonic status epilepticus following repeated oral ingestion of
colloidal silver.
Mirsattari SM, Hammond RR, Sharpe MD, Leung FY, Young GB.
Department of Clinical Neurological Sciences, University of Western
Ontario, London, Ontario, Canada.
The authors report a case of a 71-year-old man who developed myoclonic
status epilepticus and coma after daily ingestion of colloidal silver
for 4 months resulting in high levels of silver in plasma,
erythrocytes, and CSF. Despite plasmapheresis, he remained in a
persistent vegetative state until his death 5.5 months later. Silver
products can cause irreversible neurologic toxicity associated with
poor outcome.
Publication Types:
Case Reports
PMID: 15111684 [PubMed - indexed for MEDLINE]
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Int J Dermatol. 2003 Jul;42(7):549. Related Articles, Links
Argyria associated with colloidal silver supplementation.
McKenna JK, Hull CM, Zone JJ.
Department of Dermatology, University of Utah, Salt Lake City, UT
84132, USA.
A 65-year-old male presented for skin examination and was incidentally
noted to have discoloration of the fingernails. These findings were
completely asymptomatic. The patient had been taking colloidal silver
supplementation (Silverzone 140 ppm silver Gifts of Nature, St. George,
UT, USA) for 2 years as therapy for diabetes. He first noticed the
onset of nail discoloration 1 year ago. His past medical history
included type II diabetes and hypertension. His current medications
were metformin, glyburide, and benazepril. Physical examination
revealed slate-gray discoloration involving the lunulae of the
fingernails (Fig. 1). The skin, mucous membranes, and sclerae were
unaffected.
Publication Types:
Case Reports
PMID: 12839605 [PubMed - indexed for MEDLINE]
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Clin Exp Dermatol. 2003 May;28(3):254-6. Related Articles, Links
Severe generalized argyria secondary to ingestion of colloidal silver
protein.
White JM, Powell AM, Brady K, Russell-Jones R.
Department of Dermatology, Ealing Hospital, London, UK.
jonathanmlwhite@hotmail.com
Argyria is a rare cause of cutaneous discolouration caused by silver
deposition. We report a case of dramatic and diffuse argyria secondary
to ingestion of colloidal silver protein over a 1-year period. Stained
electron microscopy with spectral analysis was used to confirm the
clinical diagnosis. Silver-protein complexes are deposited in the skin
and reduced to inert silver salts by sunlight in a process similar to
that harnessed in photography. Our patient had obtained the silver for
consumption via mail order. It had been advertised as a cure for a
variety of diseases. Colloidal silver protein is commercially available
as a 'food supplement', hence circumventing the strict controls placed
on medicines.
Publication Types:
Case Reports
PMID: 12780705 [PubMed - indexed for MEDLINE]
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J Wound Care. 2003 Mar;12(3):120. Related Articles, Links
Controversies over colloidal silver.
Lansdown AB.
Publication Types:
Letter
PMID: 12677875 [PubMed - indexed for MEDLINE]
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Cutis. 2000 Nov;66(5):373-4. Related Articles, Links
Argyria following the use of dietary supplements containing colloidal
silver protein.
Gulbranson SH, Hud JA, Hansen RC.
Good Samaritan Regional Medical Center, Phoenix, Arizona 85006, USA.
The onset of argyria following the use of dietary supplements
containing colloidal silver protein is presented. The patient was using
a silver-containing product for cold and allergy prophylaxis. We review
the past and present medicinal roles of silver and include a
differential diagnosis for argyria. The hyperpigmentation of argyria is
usually permanent, and it follows a sun-exposed distribution. This case
report highlights the potential for toxicity following the use of
dietary supplements and demonstrates the importance of physician
inquiry regarding alternative medicines. Finally, we examine the
limited role of the Food and Drug Administration (FDA) in regulating
alternative medicines marketed as dietary supplements.
Publication Types:
Case Reports
PMID: 11107524 [PubMed - indexed for MEDLINE]
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Fed Regist. 1999 Aug 17;64(158):44653-8. Related Articles, Links
Over-the-counter drug products containing colloidal silver ingredients
or silver salts. Department of Health and Human Services (HHS), Public
Health Service (PHS), Food and Drug Administration (FDA). Final rule.
[No authors listed]
The Food and Drug Administration (FDA) is issuing a final rule
establishing that all over-the-counter (OTC) drug products containing
colloidal silver ingredients or silver salts for internal or external
use are not generally recognized as safe and effective and are
misbranded. FDA is issuing this final rule because many OTC drug
products containing colloidal silver ingredients or silver salts are
being marketed for numerous serious disease conditions and FDA is not
aware of any substantial scientific evidence that supports the use of
OTC colloidal silver ingredients or silver salts for these disease
conditions.
PMID: 10558603 [PubMed - indexed for MEDLINE]
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J Toxicol Clin Toxicol. 1996;34(1):119-26. Related Articles, Links
Silver products for medical indications: risk-benefit assessment.
Fung MC, Bowen DL.
Center of Drug Evaluation and Research, Food and Drug Administration,
Rockville, Maryland, USA.
BACKGROUND: Legitimate medicinal use of silver-containing products has
dramatically diminished over the last several decades. Recently,
however, some manufacturers have begun to enthusiastically promote oral
colloidal silver proteins as mineral supplements and for prevention and
treatment of many diseases. Indiscriminate use of silver products can
lead to toxicity such as argyria. OBJECTIVE: To assist health care
professionals in a risk versus benefit assessment of over-the-counter
silver-containing products, we herein examine the following issues:
historical uses, chemistry, pharmacology, clinical toxicology, case
reports of adverse events in the literature, and the recent promotion
of over-the-counter silver products. Other sources of silver exposure
(including environmental and dietary) and EPA exposure standards are
discussed. A list of currently available silver products is provided
for easy reference and screening. CONCLUSIONS: We emphasize the lack of
established effectiveness and potential toxicity of these products.
Publication Types:
Review
Review, Tutorial
PMID: 8632503 [PubMed - indexed for MEDLINE]
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JAMA. 1995 Oct 18;274(15):1196-7. Related Articles, Links
Colloidal silver proteins marketed as health supplements.
Fung MC, Weintraub M, Bowen DL.
Publication Types:
Letter
PMID: 7563503 [PubMed - indexed for MEDLINE]
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