Re: Silver Causes AGYRIA AND STATUS EPILECTUS BEWARE!
a_weisman_at_yahoo.com
Date: 02/09/05
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Date: 9 Feb 2005 08:38:59 -0800
Checkmate Brent!
a_weisman@yahoo.com wrote:
> J Wound Care. 2004 Apr;13(4):154-5. Related Articles, Links
>
>
> Colloidal silver as an antimicrobial agent: fact or fiction?
>
> van Hasselt P, Gashe BA, Ahmad J.
>
> Ear Clinic, Bamalete Lutheran Hospital, Ramotswa, Botswana.
> pvhasselt@planet.nl
>
> OBJECTIVE: Colloidal silver preparations are marketed on the internet
> as omnipotent antimicrobial agents, but scientific support for these
> claims is lacking. This study reports the results of in vitro tests
of
> colloidal silver's antimicrobial activity against several pathogenic
or
> non-pathogenic microorganisms. METHOD: Three samples of colloidal
> silver were tested: one available commercially on the internet
(silver
> concentration of 22 ppm) and two samples (concentrations of 403 and
413
> ppm) which were prepared in our laboratory using standard chemical
> methods. RESULTS: In an agar-well diffusion assay none of the three
> colloidal silver solutions had any effect on the growth of the test
> organisms. All tested bacterial strains were sensitive to
> ciprofloxacin. Colloidal silver 22 ppm showed no bactericidal
activity
> in phenol coefficient tests. CONCLUSION: As the tested colloidal
silver
> solutions did not show any antimicrobial effect in vitro on the
> microorganisms, claims of colloidal silver's antimicrobial potency
are
> misleading and there is no place for it as an antiseptic.
>
> Publication Types:
> Evaluation Studies
>
> PMID: 15114827 [PubMed - indexed for MEDLINE]
>
-------------------------------------------------------------------Neurology.
> 2004 Apr 27;62(8):1408-10. Related Articles, Links
>
>
> Myoclonic status epilepticus following repeated oral ingestion of
> colloidal silver.
>
> Mirsattari SM, Hammond RR, Sharpe MD, Leung FY, Young GB.
>
> Department of Clinical Neurological Sciences, University of Western
> Ontario, London, Ontario, Canada.
>
> The authors report a case of a 71-year-old man who developed
myoclonic
> status epilepticus and coma after daily ingestion of colloidal silver
> for 4 months resulting in high levels of silver in plasma,
> erythrocytes, and CSF. Despite plasmapheresis, he remained in a
> persistent vegetative state until his death 5.5 months later. Silver
> products can cause irreversible neurologic toxicity associated with
> poor outcome.
>
> Publication Types:
> Case Reports
>
> PMID: 15111684 [PubMed - indexed for MEDLINE]
> -------------------------------------------------------------------
>
> Int J Dermatol. 2003 Jul;42(7):549. Related Articles, Links
>
>
> Argyria associated with colloidal silver supplementation.
>
> McKenna JK, Hull CM, Zone JJ.
>
> Department of Dermatology, University of Utah, Salt Lake City, UT
> 84132, USA.
>
> A 65-year-old male presented for skin examination and was
incidentally
> noted to have discoloration of the fingernails. These findings were
> completely asymptomatic. The patient had been taking colloidal silver
> supplementation (Silverzone 140 ppm silver Gifts of Nature, St.
George,
> UT, USA) for 2 years as therapy for diabetes. He first noticed the
> onset of nail discoloration 1 year ago. His past medical history
> included type II diabetes and hypertension. His current medications
> were metformin, glyburide, and benazepril. Physical examination
> revealed slate-gray discoloration involving the lunulae of the
> fingernails (Fig. 1). The skin, mucous membranes, and sclerae were
> unaffected.
>
> Publication Types:
> Case Reports
>
> PMID: 12839605 [PubMed - indexed for MEDLINE]
>
-------------------------------------------------------------------Clin
> Exp Dermatol. 2003 May;28(3):254-6. Related Articles, Links
>
>
> Severe generalized argyria secondary to ingestion of colloidal silver
> protein.
>
> White JM, Powell AM, Brady K, Russell-Jones R.
>
> Department of Dermatology, Ealing Hospital, London, UK.
> jonathanmlwhite@hotmail.com
>
> Argyria is a rare cause of cutaneous discolouration caused by silver
> deposition. We report a case of dramatic and diffuse argyria
secondary
> to ingestion of colloidal silver protein over a 1-year period.
Stained
> electron microscopy with spectral analysis was used to confirm the
> clinical diagnosis. Silver-protein complexes are deposited in the
skin
> and reduced to inert silver salts by sunlight in a process similar to
> that harnessed in photography. Our patient had obtained the silver
for
> consumption via mail order. It had been advertised as a cure for a
> variety of diseases. Colloidal silver protein is commercially
available
> as a 'food supplement', hence circumventing the strict controls
placed
> on medicines.
>
> Publication Types:
> Case Reports
>
> PMID: 12780705 [PubMed - indexed for MEDLINE]
> -------------------------------------------------------------------J
> Wound Care. 2003 Mar;12(3):120. Related Articles, Links
>
>
> Controversies over colloidal silver.
>
> Lansdown AB.
>
> Publication Types:
> Letter
>
> PMID: 12677875 [PubMed - indexed for MEDLINE]
>
> -------------------------------------------------------------------
>
> Cutis. 2000 Nov;66(5):373-4. Related Articles, Links
>
>
> Argyria following the use of dietary supplements containing colloidal
> silver protein.
>
> Gulbranson SH, Hud JA, Hansen RC.
>
> Good Samaritan Regional Medical Center, Phoenix, Arizona 85006, USA.
>
> The onset of argyria following the use of dietary supplements
> containing colloidal silver protein is presented. The patient was
using
> a silver-containing product for cold and allergy prophylaxis. We
review
> the past and present medicinal roles of silver and include a
> differential diagnosis for argyria. The hyperpigmentation of argyria
is
> usually permanent, and it follows a sun-exposed distribution. This
case
> report highlights the potential for toxicity following the use of
> dietary supplements and demonstrates the importance of physician
> inquiry regarding alternative medicines. Finally, we examine the
> limited role of the Food and Drug Administration (FDA) in regulating
> alternative medicines marketed as dietary supplements.
>
> Publication Types:
> Case Reports
>
> PMID: 11107524 [PubMed - indexed for MEDLINE]
>
> -------------------------------------------------------------------
>
> Fed Regist. 1999 Aug 17;64(158):44653-8. Related Articles, Links
>
>
> Over-the-counter drug products containing colloidal silver
ingredients
> or silver salts. Department of Health and Human Services (HHS),
Public
> Health Service (PHS), Food and Drug Administration (FDA). Final rule.
>
> [No authors listed]
>
> The Food and Drug Administration (FDA) is issuing a final rule
> establishing that all over-the-counter (OTC) drug products containing
> colloidal silver ingredients or silver salts for internal or external
> use are not generally recognized as safe and effective and are
> misbranded. FDA is issuing this final rule because many OTC drug
> products containing colloidal silver ingredients or silver salts are
> being marketed for numerous serious disease conditions and FDA is not
> aware of any substantial scientific evidence that supports the use of
> OTC colloidal silver ingredients or silver salts for these disease
> conditions.
>
> PMID: 10558603 [PubMed - indexed for MEDLINE]
>
> -------------------------------------------------------------------
>
> J Toxicol Clin Toxicol. 1996;34(1):119-26. Related Articles, Links
>
>
> Silver products for medical indications: risk-benefit assessment.
>
> Fung MC, Bowen DL.
>
> Center of Drug Evaluation and Research, Food and Drug Administration,
> Rockville, Maryland, USA.
>
> BACKGROUND: Legitimate medicinal use of silver-containing products
has
> dramatically diminished over the last several decades. Recently,
> however, some manufacturers have begun to enthusiastically promote
oral
> colloidal silver proteins as mineral supplements and for prevention
and
> treatment of many diseases. Indiscriminate use of silver products can
> lead to toxicity such as argyria. OBJECTIVE: To assist health care
> professionals in a risk versus benefit assessment of over-the-counter
> silver-containing products, we herein examine the following issues:
> historical uses, chemistry, pharmacology, clinical toxicology, case
> reports of adverse events in the literature, and the recent promotion
> of over-the-counter silver products. Other sources of silver exposure
> (including environmental and dietary) and EPA exposure standards are
> discussed. A list of currently available silver products is provided
> for easy reference and screening. CONCLUSIONS: We emphasize the lack
of
> established effectiveness and potential toxicity of these products.
>
> Publication Types:
> Review
> Review, Tutorial
>
> PMID: 8632503 [PubMed - indexed for MEDLINE]
>
>
> -------------------------------------------------------------------
>
> JAMA. 1995 Oct 18;274(15):1196-7. Related Articles, Links
>
>
> Colloidal silver proteins marketed as health supplements.
>
> Fung MC, Weintraub M, Bowen DL.
>
> Publication Types:
> Letter
>
> PMID: 7563503 [PubMed - indexed for MEDLINE]
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