chronic manifestations of Lyme disease may occur months to years after the acute infection

From: georgia (jwissmille_at_aol.com)
Date: 02/20/05 

Date: 19 Feb 2005 16:11:49 -0800

ARTICLE
Azithromycin Compared with Amoxicillin in the Treatment of Erythema
Migrans
A Double-Blind, Randomized, Controlled Trial
 Benjamin J. Luft, MD; Raymond J. Dattwyler, MD; Russell C. Johnson,
PhD; Steven W. Luger, MD; Elizabeth M. Bosler, MPH; Daniel W. Rahn, MD;
Edwin J. Masters, MD; Edgar Grunwaldt, MD; and Shrikant D. Gadgil, MD

1 May 1996 | Volume 124 Issue 9 | Pages 785-791

".......It is important to note that the chronic manifestations of Lyme
disease may occur months to years after the acute infection and that
our study was limited to a 180-day follow-up period. Future studies
with longer follow-up are needed to establish the true failure rate and
long-term sequelae associated with these therapeutic regimens. Our
study emphasizes the benefits of a double-blind, prospective study
design in assessing therapy for an infectious disease for which
long-term follow-up is necessary and clinical criteria are the sole
measure of efficacy. ...."