2002: Bb in rats administered an acute oral regimen of ethanol
- From: "CaliforniaLyme" <CaliforniaLyme@xxxxxx>
- Date: 28 Apr 2005 08:27:15 -0700
Good reason not to drink!!!!!!!!!!
&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&
1: Clin Diagn Lab Immunol. 2002 Mar;9(2):282-6. Related Articles, Links
Impaired bactericidal activity and host resistance to Listeria
monocytogenes and Borrelia burgdorferi in rats administered an acute
oral regimen of ethanol.
Pavia CS, Harris CM, Kavanagh M.
Department of Microbiology, New York College of Osteopathic Medicine of
the New York Institute of Technology, Old Westbury, New York 11568,
USA. cpavia@xxxxxxxxxxxxx
A rat model was used to examine how ethanol ingestion may interfere
with antimicrobial immunity both in vitro and in vivo. Nonimmune
Long-Evans rats were given a short-course treatment orally with
excessive amounts of ethanol. Their spleens were removed at the time of
sacrifice, and separate spleen cell suspensions were prepared and
tested in vitro for their ability to kill two bacterial pathogens,
Listeria monocytogenes and Borrelia burgdorferi. After the bacteria
were mixed separately with various concentrations of spleen cells, it
was found that spleen cells from the ethanol-treated rats killed fewer
bacteria than matching pair-fed controls, based on counts of the number
of cultured CFU (for Listeria) or based on microscopic examination (for
Borrelia). For the in vivo studies, ethanol-treated and control rats
were infected intraperitoneally with Listeria, and then, 1 to 3 days
later, they were assessed for systemic infection based on the numbers
of organisms present in their livers and spleens. Numbers of bacterial
CFU for both organs were significantly higher in the group fed ethanol
for the first 2 days after listerial challenge. These results support
the concept that acute exposure to high levels of ethanol can impair
host defense mechanisms, especially those expressed at the cellular
level, which could lead to increased susceptibility to certain types of
infections.
PMID: 11874864 [PubMed - indexed for MEDLINE]
.
- Follow-Ups:
- Prev by Date: Re: pig driteman
- Next by Date: Yale 2000: Possible implications of multiple variants for Lyme disease persistence.
- Previous by thread: The Lyme Enigma
- Next by thread: Re: 2002: Bb in rats administered an acute oral regimen of ethanol
- Index(es):
Relevant Pages
|
