1996: These "atypical" forms of B. burgdorferi may represent in vivo morphologic variants of this bacterium.
- From: "CaliforniaLyme" <CaliforniaLyme@xxxxxx>
- Date: 28 Apr 2005 08:34:03 -0700
1: Am J Dermatopathol. 1996 Dec;18(6):571-9. Related Articles, Links
Heterogeneity of Borrelia burgdorferi in the skin.
Aberer E, Kersten A, Klade H, Poitschek C, Jurecka W.
Department of Dermatology, University of Vienna, Austria.
The reliability of various in vitro techniques to identify Borrelia
burgdorferi infection is still unsatisfactory. Using a high-power
resolution videomicroscope and staining with the borrelia
genus-specific monoclonal flagellar antibody H9724, we identified
borrelial structures in skin biopsies of erythema chronicum migrans
(from which borrelia later was cultured), of acrodermatitis chronica
atrophicans, and of morphea. In addition to typical borreliae, we noted
stained structures of varying shapes identical to borreliae found in a
"borrelia-injected skin" model; identical to agar-embedded borreliae;
and identical to cultured borreliae following exposure to hyperimmune
sera and/or antibiotics. We conclude that the H9724-reactive structures
represent various forms of B. burgdorferi rather than staining
artifacts. These "atypical" forms of B. burgdorferi may represent in
vivo morphologic variants of this bacterium.
PMID: 8989928 [PubMed - indexed for MEDLINE]
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