that prolonged courses of antibiotics may be beneficial in this setting, since 90% of the patients showed excellent or good treatment responses.

1: Eur J Clin Microbiol Infect Dis. 1998 Oct;17(10):715-9. Related
Articles, Links


Comparison of oral cefixime and intravenous ceftriaxone followed by
oral amoxicillin in disseminated Lyme borreliosis.

Oksi J, Nikoskelainen J, Viljanen MK.

Department of Medicine, Turku University Central Hospital, Finland.

Two treatment regimens for disseminated Lyme borreliosis (mainly
neurologic and musculoskeletal manifestations) were compared in a
randomized trial. A group of 30 patients received oral cefixime 200 mg
combined with probenecid 500 mg three times daily for 100 days. Another
group of 30 patients received intravenous ceftriaxone 2 g daily for 14
days followed by oral amoxicillin 500 mg combined with probenecid 500
mg three times daily for 100 days. There was no statistically
significant difference in the outcome of infection between the two
groups. However, the total number of patients with relapses or no
response at all and the number of positive polymerase chain reaction
findings after therapy were greater in the cefixime group. The general
outcomes of infection in patients with disseminated Lyme borreliosis
after 3-4 months of therapy indicate that prolonged courses of
antibiotics may be beneficial in this setting, since 90% of the
patients showed excellent or good treatment responses.

Publication Types:
Clinical Trial
Randomized Controlled Trial

PMID: 9865985 [PubMed - indexed for MEDLINE]

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