2005: Distinct bacterial dissemination and disease outcome in mice
- From: "CaliforniaLyme" <CaliforniaLyme@xxxxxx>
- Date: 14 Jun 2005 08:23:59 -0700
1: FEMS Immunol Med Microbiol. 2005 Jun 8; [Epub ahead of print]
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Distinct bacterial dissemination and disease outcome in mice
subcutaneously infected with Borrelia burgdorferi in the midline of the
back and the footpad.
Motameni AR, Bates TC, Juncadella IJ, Petty C, Hedrick MN, Anguita J.
Department of Biology, University of North Carolina at Charlotte, 9201
University City Blvd, Charlotte, NC 28223, United States.
Subcutaneous inoculation of mice with Borrelia burgdorferi, the
causative agent of Lyme disease, results in established infection and
the development of acute arthritis and carditis, hallmarks of human
disease. Because conflicting results may originate from the site of
subcutaneous inoculation, we addressed the dissemination capacity of
spirochetes injected in the shoulder region versus the footpad.
Spirochetes inoculated in the footpad disseminated to a lesser extent
to distant organs, such as the ear and the heart. This resulted in
distinct degrees of joint and cardiac inflammation at the peak of the
disease. The differences eventually leveled out. These results suggest
that caution must be exercised in the interpretation of results
obtained with routes of inoculation that do not closely represent the
natural site of infection.
PMID: 15949929 [PubMed - as supplied by publisher]
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