2004: may be used to monitor course of the disease

1: Przegl Epidemiol. 2004;58(3):451-8. Related Articles, Links


[Activity of lysosomal exoglycosidases in serum of patients with
chronic borrelia arthritis]

[Article in Polish]

Wielgat P, Pancewicz S, Hermanowska-Szpakowicz T, Kondrusik M,
Zajkowska J, Grygorczuk S, Popko J, Zwierz K.

Zaklad Biochemii Farmaceutycznej AM w Bialymstoku.

To estimate activities of lisosomal exoglycosidases in serum of
patients with chronic borrelia arthritis. Study group consisted of 18
patients aged 18-72 years (x=46) hospitalized in Department of
Infectious Diseases and Neuroinfections of Medical Academy in Bialystok
with diagnosis of chronic arthritis in course of borreliosis. Control
consisted of 20 healthy volunteers (health services employees) aged
25-65 years (x=45), with no detectable anti-Borrelia burgdorferi
antibodies in serum. In all borreliosis patients serum activity of:
N-acetyl-beta-D-glucosaminidase (HEX), beta-galactosidase and
alpha-mannosidase was measured before and after 4 weeks of doxycycline
treatment. Results were analyzed with Statistica 6.0 software. P < 0.05
was considered statistically significant. HEX activity was
significantly increased in serum of Lyme arthritis patients before
treatment compared to controls. It decreased after 4-week treatment,
remaining insignificantly higher than in controls. b-galactosidase and
a-mannosidase activities in serum of Lyme arthritis patients were
insignificantly higher than in controls and fell after treatment to the
levels observed in control group. N-acetyl-beta-D-glucosaminidase (HEX)
is sensitive enzymatic marker of Lyme arthritis. It may be used to
monitor course of the disease and its efficiency of treatment.

PMID: 15730009 [PubMed - indexed for MEDLINE]

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