2005: Murine microglia are effective phagocytes for Borrelia burgdorferi.

1: J Neuroimmunol. 2005 Aug 23; [Epub ahead of print] Related Articles,
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Murine microglia are effective phagocytes for Borrelia burgdorferi.

Kuhlow CJ, Garcia-Monco JC, Coleman JL, Benach JL.

Center for Infectious Diseases, SUNY at Stony Brook, Stony Brook, New
York 11794-5120, United States; State of New York Department of Health,
SUNY at Stony Brook, Stony Brook, New York 11794-5120, United States.

Lyme disease is a multi-systemic infection that causes diverse
neurologic dysfunction collectively known as neuroborreliosis. In the
murine model of Lyme disease, Borrelia burgdorferi are seldom found in
the nervous system indicating that the spirochetes are rapidly cleared
from the brain and peripheral nerves. In the present study, we examined
the interaction between microglia and B. burgdorferi. Murine microglia
are efficient phagocytes and are capable of ingesting and killing
spirochetes with or without opsonization.

PMID: 16125249 [PubMed - as supplied by publisher]

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