2005: Experimental Ehrlichia canis infection in the dog does not cause immunosuppression.
- From: "CaliforniaLyme" <CaliforniaLyme@xxxxxx>
- Date: 20 Sep 2005 08:02:52 -0700
1: Vet Immunol Immunopathol. 2005 Sep 15; [Epub ahead of print] Related
Articles, Links
Experimental Ehrlichia canis infection in the dog does not cause
immunosuppression.
Hess PR, English RV, Hegarty BC, Brown GD, Breitschwerdt EB.
Department of Clinical Sciences, College of Veterinary Medicine, North
Carolina State University, Box 8401, 4700 Hillsborough Street, Raleigh,
NC 27606, USA.
A carrier state develops in some Ehrlichia canis-infected dogs due to
ineffective host defenses. The subsequent development of
immune-mediated diseases or opportunistic infections in chronic
ehrlichiosis suggests dysregulation of immunity; however, the
immunobiology of this infection has not been well characterized. In
this study, eight dogs were infected with E. canis, and changes in
seroreactivity, serum immunoglobulin (Ig) concentrations, peripheral
blood T cell subsets, lymphocyte blastogenesis (LBT), and
lymphokine-activated killer (LAK) activity were evaluated over 4
months. Infection, which was documented by seroconversion, polymerase
chain reaction, and blood culture, caused self-limiting fever and
thrombocytopenia. Infected dogs developed an anti-E. canis antibody
response but were not immune to re-infection. Serum IgM, IgG, and IgA
concentrations were unaffected by E. canis. The percentage of
circulating CD4(+) T cells was similar in uninfected and infected dogs
at all points. Infected dogs developed a CD8(+) lymphocytosis 6 weeks
after inoculation that subsequently subsided, despite organism
persistence. Functional defects of cell-mediated immunity, measured as
suppression of LAK activity or mitogen-driven LBT, were not observed.
These results suggest that immune responses are not grossly impaired in
young dogs during the first several months following experimental E.
canis infection.
PMID: 16169601 [PubMed - as supplied by publisher]
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