October 2005: Infection with Anaplasma phagocytophilum in a seronegative patient
- From: "CaliforniaLyme" <CaliforniaLyme@xxxxxx>
- Date: 13 Oct 2005 08:17:37 -0700
1: Ann Clin Microbiol Antimicrob. 2005 Oct 3;4(1):15 [Epub ahead of
print] Related Articles, Links
Infection with Anaplasma phagocytophilum in a seronegative patient in
Sicily, Italy: Case Report.
de la Fuente J, Torina A, Naranjo V, Caracappa S, Di Marco V, Alongi A,
Russo M, Maggio A, Kocan KM Undefined.
BACKGROUND: Anaplasma phagocytophilum causes human granulocytic
anaplasmosis (HGA) in humans, which has been recognized as an emerging
tick-borne disease in the United States and Europe. Although about 65
cases of HGA have been reported in Europe, some of them do not fulfill
the criteria for confirmed HGA. Confirmation of HGA requires A.
phagocytophilum isolation from blood, and/or identification of morulae
in granulocytes and/or positive PCR results with subsequent sequencing
of the amplicons to demonstrate specific rickettsial DNA.
Seroconversion or at least fourfold increase in antibody titers to A.
phagocytophilum has been used as criteria for confirmed HGA also. Case
presentation: Infection with A. phagocytophilum was confirmed by PCR in
a patient in Sicily, Italy, who had negative serology for A.
phagocytophilum. A fragment of A. phagocytophilum 16S rDNA was
amplified by two independent laboratories and sequenced from two
separate patient's blood samples. The 16S rDNA sequence was identical
in both samples and identical to the sequence of the A. phagocytophilum
strain USG3 originally obtained from a dog. Conclusions: Infection with
A. phagocytophilum was confirmed in a patient without a detectable
antibody response against the pathogen. The results reported herein
documented the first case of confirmed HGA in Sicily, Italy. These
results suggested the possibility of human infections with A.
phagocytophilum strains that result in clinical symptoms and laboratory
findings confirmatory of HGA but without detectable antibodies against
the pathogen.
PMID: 16202127 [PubMed - as supplied by publisher]
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