excerpt from flaG patent, very interesting

The flagellin polypeptides of this invention provide a high degree of
diagnostic sensitivity, while keeping diagnostic specificity at a high
level as well. One of skill in the art will understand that while
larger flagellin polypeptides may be more sensitive, additional
flagellin sequences may result in a decrease in specificity. Using the
teachings of this invention, however, one of skill in the art can
easily make modifications or derivatives of the immunodominant regions
within the flagellin polypeptides with the aim of increasing both
sensitivity and specificity. For example, any domains in a highly
sensitive immunodominant region which are found to have low levels of
cross-reactivity with antibodies directed against bacteria and other
treponemes could be masked or blocked by constructing a flagellin
polypeptide containing modifications or derivatives of the
immunodominant region in accordance with the teachings of this
invention. In this way the specificity of the flagellin polypeptide may
be increased without any concomitant decrease in sensitivity.

One of skill in the art will also understand that the effectiveness of
the flagellin polypeptides of this invention as diagnostic agents may
be enhanced by combining them with other B. burgdorferi antigens, such
as OspA or OspB or fragments thereof. Antibodies directed against OspA
and OspB will not cross react with the antigens of bacteria and other
treponemes, while at the same time, antibodies directed against the
flagellin polypeptide are detectable at earlier stages of the disease
than OspA and OspB.

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Relevant Pages

  • Re: Ed/Chuck McSweegan is involved in the Lyme scam- JAIL FOR ED
    ... diagnostic sensitivity, while keeping diagnostic specificity at a high ... larger flagellin polypeptides may be more sensitive, ... flagellin sequences may result in a decrease in specificity. ... teachings of this invention, however, one of skill in the art can ...
    (sci.med.diseases.lyme)
  • Re: Ed/Chuck McSweegan is involved in the Lyme scam- JAIL FOR ED
    ... you will see that the Yale Flagellin method was completely ... > diagnostic sensitivity, while keeping diagnostic specificity at a high ... > larger flagellin polypeptides may be more sensitive, ... > flagellin sequences may result in a decrease in specificity. ...
    (sci.med.diseases.lyme)