2006: Lyme Disease: The Quest for Magic Bullets.

1: Chemotherapy. 2006 Feb 22;52(2):53-59 [Epub ahead of print] Related
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Lyme Disease: The Quest for Magic Bullets.

Stricker RB, Lautin A, Burrascano JJ.

California Pacific Medical Center, San Francisco, Calif., USA.

Lyme disease represents a growing public health threat. Recent
molecular and genetic studies have confirmed that Borrelia burgdorferi,
the spirochetal agent of Lyme disease, is one of the most complex
bacteria known to man. Affinity for multiple cell types and the
presence of non-replicating forms of B. burgdorferi have contributed to
persistent infection and failure of simple antibiotic regimens. The
controversial clinical science of Lyme disease has impeded reliable
diagnosis and effective treatment of this protean illness. Two major
clinical hurdles are the absence of a therapeutic endpoint in
treatingLyme disease and the presence of tick-borne coinfections that
may complicate the course of the illness. New strategies for the
diagnosis, treatment and prevention of Lyme disease are urgently
needed. Copyright (c) 2006 S. Karger AG, Basel.

PMID: 16498239 [PubMed - as supplied by publisher]

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