2006: post-Lyme disease syndrome in adult patients.

1: Int J Med Microbiol. 2006 Mar 6; [Epub ahead of print] Related
Articles, Links


Clinical aspects of neuroborreliosis and post-Lyme disease syndrome in
adult patients.

Pfister HW, Rupprecht TA.

Department of Neurology, Ludwig-Maximilians-University, Klinikum
Grosshadern, Marchioninistrasse 15, D-81377 Munich, Germany.

The diagnostic criteria of active neuroborreliosis include inflammatory
changes of the cerebrospinal fluid (CSF) and an elevated specific
Borrelia CSF-to-serum antibody index, indicating intrathecal Borrelia
antibody production. Patients with neuroborreliosis are usually treated
with intravenous ceftriaxone for 2-3 weeks. In case of allergy,
doxycycline may be used. Treatment efficacy is detected by the
improvement of the neurological symptoms and the normalization of the
CSF pleocytosis. The measurement of serum and CSF antibodies is not
suitable for follow-up, because they frequently persist. Post-Lyme
disease (PLD) syndrome is characterized by persistent complaints and
symptoms after previous treatment for Lyme borreliosis, e.g.,
musculoskeletal or radicular pain, dysaesthesia, and neurocognitive
symptoms that are often associated with fatigue. There is no formal
definition of the PLD syndrome, and its pathogenesis is unclear. Recent
controlled studies do not support the use of additional antibiotics in
these patients, but recommend primarily symptomatic strategies.

PMID: 16524775 [PubMed - as supplied by publisher]

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