Alzheimer's disease--a spirochetosis? [ Lyme disease ]

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Complete article: Alzheimer's disease--a spirochetosis?, Miklossy J,
Neuroreport 1993 Jul;4(7):841-8
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as of 23 September
1998

NeuroReport 4, §41-§48 (1993)
NeuroReport Vol. 4 No. 7 July 1993 [pages 841-848]

Alzheimer's disease--a spirochetosis?

Judit Miklossy

University Institute of Pathology, Division of Neuropathology,
University of Lausanne, Rue du Bugnon 27, 1005 Lausanne, Switzerland

The aetiology of Alzheimer's disease (AD), which affects a large
proportion of the aged population is unknown and the treatment
unresolved. The role of beta amyloid protein (ßA4), derived from a
larger amyloid precursor protein (APP) in AD is the subject of intense
research. Here I report observations that in 14 autopsy cases, with
histopathologically confirmed AD, spirochetes were found in blood and
cerebrospinal fluid and, moreover, could be isolated from brain tissue.

Thirteen age-matched control cases were without spirochetes. Reference
strains of spirochetes and those isolated from brains of AD patients,
showed
positive immunoreaction with monoclonal antibody against the ß amyloid
precursor protein. These observations suggest that spirochetes may be
one
of the causes of AD and that they may be the source of the ß amyloid
deposited in the AD brain.

.