Artemisia for METASTATIC MELANOMA if you know anyone (and lung cancer!)
- From: CaliforniaLyme <CaliforniaLyme@xxxxxx>
- Date: 9 May 2007 08:53:29 -0700
It has already been studied re BREAST cancer and now LUNG cancer!!!
Also leukemia, colon cancer and METASTATIC END STAGE melanoma!!!
GREAT STUFF!!!!!!!!!
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1: Oncol Rep. 2005 Dec;14(6):1599-603. Links
Artesunate in the treatment of metastatic uveal melanoma--first
experiences.Berger TG, Dieckmann D, Efferth T, Schultz ES, Funk JO,
Baur A, Schuler G.
Department of Dermatology, University Hospital of Erlangen, Erlangen,
Germany. thomas.berger@xxxxxxxxxxxxxxxxxxxxxxxxxx
Artesunate (ART) is a derivative of artemisinin, the active principle
of the Chinese herb Artemisia annua L. Artesunate is approved for the
treatment of multidrug-resistant malaria and has an excellent safety
profile.
It has been shown that Artesunate, apart from its anti-malarial
activity, has cytotoxic effects on a number of human cancer cell
lines, including leukemia, colon cancer and melanoma. We report on the
first long-term treatment of two cancer patients with ART in
combination with standard chemotherapy.
These patients with metastatic uveal melanoma were treated on a
compassionate-use basis, after standard chemotherapy alone was
ineffective in stopping tumor growth. The therapy-regimen was well
tolerated with no additional side effects other than those caused by
standard chemotherapy alone.
One patient experienced a temporary response after the addition of ART
to Fotemustine while the disease was progressing under therapy with
Fotemustine alone.
The second patient first experienced a stabilization of the disease
after the addition of ART to Dacarbazine, followed by objective
regressions of splenic and lung metastases.
This patient is still alive 47 months after first diagnosis of stage
IV uveal melanoma, a situation with a median survival of 2-5 months.
Despite the small number of treated patients, ART might be a promising
adjuvant drug for the treatment of melanoma and possibly other tumors
in combination with standard chemotherapy.
Its good tolerability and lack of serious side effects will facilitate
prospective randomized trials in the near future.
PMID: 16273263
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1: Methods Find Exp Clin Pharmacol. 2007 Jan-Feb;29(1):33-8. Links
Calcium and survivin are involved in the induction of apoptosis by
dihydroartemisinin in human lung cancer SPC-A-1 cells.Mu D, Chen W, Yu
B, Zhang C, Zhang Y, Qi H.
Department of Respiratory Disease, Tangdu Hospital, Fourth Military
Medical University, Xi'an, China.
Dihydroartemisinin (DHA), a semisynthetic derivative of artemisinin
isolated from the traditional Chinese herb Artemisia annua, is an
effective novel antimalarial drug. Recent studies suggest that it also
has anticancer effects.
The present study investigated the apoptosis activity of DHA in
cultured human lung cancer cells by terminal deoxynucleotidyl
transferase dUTP nick-end labelling (TUNEL) assay and flow cytometry.
Intracellular free calcium concentrations in the lung cancer cells
were evaluated by laser scanning confocal microscopy using Fura-3/AM
as probe. The observations also indicated that DHA downregulated the
mRNA and protein expression level of survivin in the lung cancer cell
line SPC-A-1 cells, whereas it did not affect those of caspase-4.
These results demonstrated that DHA can induce apoptosis of lung
cancer cell line SPC-A-1 cells and that calcium and survivin
participated in the apoptotic signalling pathways. (c) 2007 Prous
Science. All rights reserved.
PMID: 17344942
--------------------
There is no wealth but life.
-John Ruskin
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