DORWARD- TRAINING SPIROCHETES TO BE CERTAIN TISSUE TROPIC (was: Researchers track Lyme disease spirochetes
- From: Mort Zuckerman <morph410@xxxxxxxxx>
- Date: Sat, 21 Jun 2008 08:23:55 -0700 (PDT)
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Subject: DORWARD- TRAINING SPIROCHETES TO BE CERTAIN TISSUE TROPIC
(was: Researchers track Lyme disease spirochetes
Date: Jun 21, 2008 11:21 AM
DORWARD- TRAINING SPIROCHETES TO BE CERTAIN TISSUE TROPIC:
http://iai.asm.org/cgi/content/full/69/3/1428?view=long&pmid=11179308
"By repeatedly coincubating spirochetes with primary mouse lymphocytes
that
were immobilized by adherence to immunomagnetic beads, we were able to
preferentially
enrich cultures for or against bacteria with constitutive affinity for
murine B
and T cells."
=========
http://www.actionlyme.org/CRYMEDISEASE_CHP3_B.htm
This is the famous Elephant Rule invented by Allen Steere, where he
tried to assert
that the higher the antibody concentration, the more "valid" the test,
falsely claiming that by "narrowing the number of persons who will
test positive,"
that makes his test more SPECIFIC, and by claiming that "the higher
the concentration
if antibodies in the blood makes the test more SENSITIVE," when as we
know,
SENSITIVITY is a function of LIMIT of DETECTION or the ability of the
test to detect
very low concentrations of analyte.
The new Steere fantasy term "receiver operator characteristic" is not
a criterion for the validation of an analytical method. It means the
opposite of
sensitivity.
Cross apply that to what you know from Chapter One on Chromatography
Methods Development
and Validation. No one in their right mind would buy a chromatography
detector
that detects less than what you can see with your own eyeball. No one
goes hunting
for viruses with a magnifying glass. We know from Chapter One, that
by 1991, Yale's
Erol Fikrig already made band 41 SPECIFIC by pharming sections of the
DNA from Bb
flagellin into E. coli, producing a protein fragment, and comparing
the antibodies
from the blood of people infected with known spirochetal or
flagellated infections
and found that he had captured a fragment of recomibinant flagellin
that was SPECIFIC
to Borrelia burgdorferi. Yale also claims that their recombinant
vaccine, OspA
or LYMErix, was SPECIFIC enough to prevent Lyme, so why isn't one
specific antibody
specific enough to detect Lyme?
Why was OspA left out of the diagnostic standard, if to have that
antibody from
a vaccine, that was supposedly specific enough to PREVENT "Lyme
Disease."
You can see how silly Dressler/Steere is on its face. You need 5 out
of 10 band
in order to be diagnosed with a case of Lyme, but you only needed one
antibody,
band 31, to be PROTECTED against Lyme, according to these loonies and
accepted as
a truism by the American Medical Association and all of their related
MDtards.
The reality is that each antibody band is as ACCURATE for diagnosis as
its assigned
percent specificity. If we had Steere at the helm, detecting Anthrax
during the
Mossadesque Anthrax-mailing stunt in October, 2001, well, nobody would
be too happy.
-----Original Message-----
From: Miguel <mikijean@xxxxxxxxxxxx>visualization of the dissemination of Borrelia burgdorferi, the
Sent: Jun 20, 2008 1:14 AM
To: SpinLyme@xxxxxxxxxxxxxxx
Subject: [SpinLyme] Researchers track Lyme disease spirochetes
http://www.eurekalert.org/pub_releases/2008-06/plos-rtl061808.php
Public release date: 19-Jun-2008
[ Print Article | E-mail Article | Close Window ]
Contact: Mary Kohut
Press@xxxxxxxx
415-568-3457
Public Library of Science
Researchers track Lyme disease spirochetes
Microbiologists at the University of Calgary have demonstrated the first direct
bacterium that causes
Lyme disease. This real-time, three-dimensional look at spirochete
dissemination
in a living mammalian host is published June 20th in the open-access
journal PLoS
Pathogens.
and re-emerging diseases worldwide, including syphilis, leptospirosis,
Pathogenic spirochetes are a group of bacteria that cause a number of emerging
relapsing
fever, and Lyme disease. The mechanism by which they disseminate from
the blood
to target sites is unknown. Direct visualization of these bacteria may
yield critical
insight into resultant disease processes.
level in a living host, using an engineered fluorescent strain of B.
The team therefore set out to directly observe these bacteria at the single-cell
burgdorferi
as an example bacterium. Using conventional and spinning disk confocal
microscopy,
the investigators were able to track the movement of the bacteria and
the interaction
of the bacteria with the vascular wall in mice. They found that
vascular escape
is a multi-stage process and that spirochete movement appears to play
an integral
role in dissemination from the blood to target tissue sites.
bacterial pathogen in vivo lays the groundwork for a better
This use of high-resolution, 3D imaging to visualize the dissemination of a
understanding of the
mechanisms by which these and other bacteria disseminate throughout
the body to
cause disease.
http://www.plospathogens.org/doi/ppat.1000090 (link will go live on
###
PLEASE ADD THIS LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT:
Friday, June
20)
Real-Time High Resolution 3D Imaging of the Lyme Disease Spirochete
CITATION: Moriarty TJ, Norman MU, Colarusso P, Bankhead T, Kubes P, et al. (2008)
Adhering to
and Escaping from the Vasculature of a Living Host. PLoS Pathog 4(6):
e1000090.
doi:10.1371/journal.ppat.1000090
.
CONTACT:
Jordanna Heller
Manager, Media Relations
Faculty of Medicine
University of Calgary
403.220.2431 (office)
medmedia@xxxxxxxxxxx
Dr. George Chaconas
1-403-210-9692
chaconas@xxxxxxxxxxx
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