World wide study confirms heart disease lipid risk factors

markd_at_toad-net.com
Date: 08/30/04


Date: 30 Aug 2004 10:48:32 GMT

Cholesterol remains at the top of the risk factors for heart disease,
followed by the metabolic syndrom risk factors and stress as risk factors,
all based in lifestyle and 90 percent preventable:

   Global study shows heart disease risks the same all over the world
   By EMMA ROSS, AP Medical Writer
   (Published August 29' 2004)
   MUNICH, Germany (AP) - The causes of heart disease are surprisingly
   the same in every region and race, and stress seems to play a more
   important role in heart attacks than previously recognized, a major
   new study has found.

   Nearly all of what is known about the causes of heart disease comes
   from studies of white people in rich countries, because that's where
   the illness first emerged.

   However, with the globe's No. 1 killer now taking over the developing
   world as well, scientists have been worried that the way it is tackled
   in the West - by combatting smoking, obesity, blood pressure and
   cholesterol, among other things - may not necessarily apply in poorer
   countries.

   "Some 80 percent of the heart disease in the world is in developing
   countries, yet 99 percent of the research done into the causes of
   heart disease comes from developed countries and largely white,
   European populations, so we really don't know for sure whether we can
   apply the results of the studies we've got to the rest of the world,"
   said the study's leader, Dr. Salim Yousef, a professor of medicine at
   McMaster University in Canada, explaining what prompted the study.

   The research, presented Sunday at the annual meeting of the European
   Society of Cardiology, followed 29,000 people in 52 countries. It took
   a decade and 262 scientists to complete the work, which, according to
   the editor of The Lancet medical journal, is probably the most robust
   study on heart disease risk factors ever conducted.

   The scientists, who concluded that about 90 percent of the risk
   factors for heart attacks can be prevented, are scheduled to published
   the findings in The Lancet next week.

   "This study confirms that the risk factors are the same all over the
   planet and ... has made it possible to assess the weight of the
   different risk factors," said Dr. Jean-Pierre Bassand, president of
   the European Society of Cardiology. "It's a fantastic study."

   "It is clear that not a single continent, not a single civilization,
   not a single race, can be spared from cardiovascular disease, which
   will hit humankind more dangerously than the Black Death in the Middle
   Ages," said Bassand, who was not connected with the study or the
   publication. "What we need is political action."

   The study examined 15,000 people who had suffered their first heart
   attacks and matched them with someone of the same age, sex and
   location who had not had a heart attack.

   A bad cholesterol profile, measured using a new test considered better
   than the standard one that looks at the balance between good HDL
   cholesterol and bad LDL cholesterol, was the most important risk
   factor.

   Smoking was the next most important player, followed by diabetes, high
   blood pressure and a fat belly.

   Stress came next, followed by inadequate fruit and vegetable intake,
   then lack of exercise. Light to moderate alcohol consumption was found
   to be of slight benefit.

   Yousef said he was surprised by some of the findings.

   "My expectation when I went into this was that I would find ethnic and
   regional variations, because some of our earlier papers had suggested
   that. It just shows you need massive numbers to get the right answer,"
   Yousef said. "I thought smoking would be bad everywhere, but the
   (cholesterol) I wasn't sure."

   But what was most unexpected, he said, was the power of stress.

   "The standard biomedical scientist is really not interested in stress,
   partly because they are uncomfortable with the concept, the certain
   softness with which you measure it," Yousef said. "I came into this
   with a little educated hostility regarding stress, but I've changed my
   mind after seeing the data."

   The problem is psychological, not physical, stress - things such as
   tension at home or at work, financial problems, divorce, losing a
   child, or feeling of loss of control.

   Most experts believe that about half of the risk of a heart attack can
   be prevented. The latest study, however, indicated that about 90
   percent of the causes of heart attacks can be averted.

   The study indicated that about 50 percent of the chance of having a
   heart attack comes from a bad cholesterol profile alone, Yousef said.

   "Globally, in urban populations, there's practically nobody with a
   level of (cholesterol) that avoids an increased risk of heart
   disease," he said.

   Smoking is responsible for another 36 percent of the risk, the study
   found.

   "The impact of these risk factors was the same in every ethnic group
   and in every region of the world," Yousef added. "That means
   preventive messages can be simple and we can use the same strategy, of
   course adjusted for economic and cultural circumstances, in every part
   of the world."

   The difference between men and women seen in the West was also
   observed all over the world. Men usually get heart attacks at about
   57, women at 65.

   Although that sex difference held true everywhere, the study found
   that in southern Asia, the Middle East and Africa, people suffer heart
   attacks about 10 years earlier.

   The study implies that the main way to tackle the problem is societal
   change, including better urban planning and health-promoting food
   policies and advertising regulations, experts said.

   The study comes on the heels of a World Health Organization vote in
   May to implement a global strategy on diet and exercise aimed at
   combatting obesity, diabetes, heart disease and other illness linked
   to an unhealthy lifestyle.

   



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