Re: "Lipid bilayer membranes" and your health.

From: montygram (nazztrader_at_lycos.com)
Date: 10/17/04 

Date: 16 Oct 2004 20:20:36 -0700

"Tell you what, monty,
> you go get that article published somewhere. Go on, I dare you to submit it."

I wish I could do that, Larry, but it’s already been done, and
I’m not into plagiarism. For example:

Adkisson, H.D., Tranik,T.M., & Wuthier,R.E.
Relationship of cartilage Mead acid levels to aging and development of
osteoarthritis.
Poster Presentation at the Third International Conference on Essential
Fatty Acids and Eicosanoids, Adelaide, Australia March 1 1992
“…Young cartilage is characterised by the presence of high
levels of 20:9 w-9, Mead acid, indicating a relative deficiency of
EFA. Skeletal muscle from the same subjects showed normal EFA levels,
and no Mead acid. Age decreases the Mead acid level and increases the
EFA level, with weight-bearing cartilage having more EFA and less Mead
acid than costal tissues. Cartilage from osteoarthritis affected
joints showed even lower Mead acid levels and even higher w-6 EFA
levels, leading the authors to speculate that accumulation of w-6 EFAs
in cartilage might predispose towards the development of OA, and that
the presence of Mead acid might somehow be protective.”

Or:

J Exp Med. 1993 Dec 1;178(6):2261-5.
Effect of dietary supplementation with n-9 eicosatrienoic acid on
leukotriene B4 synthesis in rats: a novel approach to inhibition of
eicosanoid synthesis.

James MJ, Gibson RA, Neumann MA, Cleland LG.

Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia.

“…Because ETrA is substantially less unsaturated than EPA,
it can be expected to have greater chemical stability, which could be
an important practical advantage when used as a dietary constituent or
supplement.”

Or:

FASEB J. 1991 Mar 1;5(3):344-53.
Unique fatty acid composition of normal cartilage: discovery of high
levels of n-9 eicosatrienoic acid and low levels of n-6
polyunsaturated fatty acids.

Adkisson HD 4th, Risener FS Jr, Zarrinkar PP, Walla MD, Christie WW,
Wuthier RE.

Department of Chemistry, University of South Carolina, Columbia 29208.

“…EFA deficiency has been shown to greatly suppress the
inflammatory response of leukocytes and rejection of tissues
transplanted into allogeneic recipients. Because eicosanoids, which
are derived from EFA, have been implicated in the inflammatory
responses associated with arthritic disease, reduction of n-6 PUFA and
accumulation of the n-9 20:3 acid in cartilage may be important for
maintaining normal cartilage structure.”

Or:

Prostaglandins Leukot Essent Fatty Acids. 1998 Dec;59(6):371-7.
Eicosatrienoic acid (20:3 n-9) inhibits the expression of E-cadherin
and desmoglein in human squamous cell carcinoma in vitro.

Eynard AR, Jiang WG, Mansel RE.

Instituto de Biologia Celular, Facultad de Ciencias Medicas,
Universidad Nacional de Cordoba, Argentina. aeynard@cmefcm.uncor.edu

Eicosatrienoic acid (ETA 5,8,11, n-9) is abnormally increased by
essential fatty acid deficiency (EFAD), a condition associated with
alterations of cell proliferation and differentiation. In comparison
to certain EFAs, addition of ETA at a low concentration resulted in a
reduction in the expression of the cell-cell adhesion molecule,
E-cadherin, and to a lesser degree, of desmoglein, along with
increased invasion of Matrigel by human squamous cell carcinoma (SCC)
cells in vitro. At higher concentrations, ETA stimulated the growth of
SCC cells. As previously shown, n-6 EFAs (mainly 18:3 n-6, GLA),
up-regulated the expression of E-cadherin and desmoglein. This is the
first report showing that the abnormal 20:3 n-9 (Mead's acid) is a
down regulator of antimetastatic E-cadherin and desmoglein expression.

Or:

Lipids. 1997 Sep;32(9):979-88.
Modulation of adjuvant-induced arthritis by dietary arachidonic acid
in essential fatty acid-deficient rats.

Chinn KS, Welsch DJ, Salsgiver WJ, Mehta A, Raz A, Obukowicz MG.
“… edema in the primary hind footpads was decreased by 87%
in EFAD…”

Or:

Lipids. 1996 Aug;31(8):829-37.
Effect of dietary n-9 eicosatrienoic acid on the fatty acid
composition of plasma lipid fractions and tissue phospholipids.

“…rats appear to tolerate high levels of dietary ETrA
without adverse effects. Dietary enrichment with ETrA warrants further
investigation for possible beneficial effects in models of
inflammation and autoimmunity, as well as in other conditions in which
mediators derived from n-6 fatty acids can affect homeostasis
adversely.”

The negative scientific papers on arachidonic acid, as well as fish
oil and flax oil, have nearly filled up my hard drive, so you can do
your own research on those. Even you, Larry, can discern how to get
to www.pubmed.com, type in arachidonic, and hit the enter key.

The question those with an open mind are probably asking themselves
is, “why aren’t there a bunch of studies in humans being
conducted now?” If you know the story of Lincoln’s
doctors, then you know the answer. The powers that be are politicians
more than anything else (they just put their name on the studies that
others do, and the studies are often statistical, with incorrect
initial assumptions – read “Heart Failure,” by
Thomas Moore, for an in depth account of this phenomenon). I’ve
done the experiment on myself – well over three years on a very
low polyunsaturate diet, and the results are outstanding. Rosacea,
which I’ve had for over a decade, is gone. Wounds head faster,
with almost no inflammation. Scabs are soft and rubbery, not hard
(which has implication for blood clots that lead to heart attacks and
strokes). Hair feels thicker and never gets that greasy quality.
Strains don’t hurt much at all.

Lincoln’s doctors were out of touch with the latest knowledge on
head wounds. They poked around in his brain. Battlefield surgeon
knew that such a wound should be left alone, otherwise serious brain
damage could be done by the doctor. This is very similar to the
current situation. There are plenty of scientists doing good
research, and they get published, write newsletters and books, etc.,
but only the connected people, who usually don’t actually do
their own research, get their papers into Science, Nature, Lancet, or
JAMA, and those are the journals your local doctor reads, if he reads
much of anything at all.

And isn't it interesting that I'm the one posting all the supporting
evidnece, and those who attack me call me "bonehead" and such, and yet
have not evidence, except perhaps for that ridiculous 1930 Burr & Burr
study on rats, in which the rats were deprived of B vitamins, among
other vital nutrients. Larry, you make it clear to anyone with a bit
of gray matter between their ears who's got the evidence and who is
just an incompetent masquarading as a "scientist."

Relevant Pages

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