Vitamin C and E supplementation / asthma

From: doe (ironjustice_at_aol.comdoe)
Date: 10/24/04 

Date: 24 Oct 2004 19:07:07 GMT

Clin Exp Immunol. 2004 Nov;138(2):317-22. Related Articles, Links

Antioxidant supplementation and nasal inflammatory responses among young
asthmatics exposed to high levels of ozone.

Sienra-Monge JJ, Ramirez-Aguilar M, Moreno-Macias H, Reyes-Ruiz NI, Del
Rio-Navarro BE, Ruiz-Navarro MX, Hatch G, Crissman K, Slade R, Devlin RB,
Romieu I.

Hospital Infantil de Mexico, Federico Gomez, Mexico.

SUMMARY The inflammatory response to ozone in atopic asthma suggests that
soluble mediators of inflammation are released in response to oxidant stress.
Antioxidants may alleviate additional oxidative stress associated with
photochemical oxidant pollution. This study investigates the impact of
antioxidant supplementation on the nasal inflammatory response to ozone
exposure in atopic asthmatic children. We conducted a randomized trial using a
double-blinded design. Children with asthma (n = 117), residents of Mexico
City, were given randomly a daily supplement of vitamins (50 mg/day of vitamin
E and 250 mg/day of vitamin C) or placebo. Nasal lavages were performed three
times during the 4-month follow-up and analysed for content of interleukin-6
(IL-6), IL-8, uric acid and glutathione (GSx). IL-6 levels in the nasal lavage
were increased significantly in the placebo group after ozone exposure while no
increase was observed in the supplement group. The difference in response to
ozone exposure between the two groups was significant (P = 0.02). Results were
similar for IL-8, but with no significant difference between the groups (P =
0.12). GSx decreased significantly in both groups. Uric acid decreased slightly
in the placebo group. Our data suggest that vitamin C and E supplementation
above the minimum dietary requirement in asthmatic children with a low intake
of vitamin E might provide some protection against the nasal acute inflammatory
response to ozone.

PMID: 15498043 [PubMed - in process]

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