Apple juice concentrate / cognition / oxidative stress

From: doe (ironjustice_at_aol.comdoe)
Date: 11/16/04 

Date: 16 Nov 2004 08:24:44 GMT

J Nutr Health Aging. 2004;8(6):492-6. Links

Dietary supplementation with apple juice concentrate alleviates the
compensatory increase in glutathione synthase transcription and activity that
accompanies dietary- and genetically-induced oxidative stress.

Tchantchou F, Graves M, Ortiz D, Rogers E, Shea TB.

TB Shea, PhD, Center for Cellular Neurobiology and Neurodegeneration Research,
Department of Biological Sciences, University of Massachusetts Lowell, One
University Avenue, Lowell, MA 01854, Tel: 978-934-2881, Fax: 978-934-3044,
Email: Thomas_Shea@uml.edu.

Increased oxidative stress, which can arise from dietary, environmental and/or
genetic sources, contributes to the decline in cognitive performance during
normal aging and in neurodegenerative conditions such as Alzheimer's disease.
Supplementation with fruits and vegetables that are high in antioxidant
potential can compensate for dietary and/or genetic deficiencies that promote
increased oxidative stress. We have recently demonstrated that apple juice
concentrate (AJC) prevents the increase in oxidative damage to brain tissue and
decline in cognitive performance observed when transgenic mice lacking
apolipoprotein E (ApoE-/-) are maintained on a vitamin-deficient diet and
challenged with excess iron (included in the diet as a pro-oxidant). However,
the mechanism by which AJC provided neuroprotection was not conclusively
determined. Herein, we demonstrate that supplementation with AJC also prevents
the compensatory increases in glutathione synthase transcription and activity
that otherwise accompany maintenance of ApoE-/- mice on this vitamin-free diet
in the presence of iron. Inclusion of the equivalent composition and
concentration of sugars of AJC did not prevent these increases. These findings
provide further evidence that the antioxidant potential of AJC can compensate
for dietary and genetic deficiencies that otherwise promote neurodegeneration.

PMID: 15543422 [PubMed - in process]

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