Re: Very low-carb diets work for men and upper body fat

From: Susan (sufein_at_aol.comnospam)
Date: 11/19/04 

Date: 19 Nov 2004 17:16:28 GMT

x-no-archive: yes

>
>1) There's particle size and there's particle numbers. Below 150 TC the
>micro environment has minimal consequence.

I disagree, for other reasons. Often, low TC is a marker for liver or other
disease or dysfunction.

>2) The other point is that type B LDL (putative artherogenic, small
>particle) has not been *independently* associated with CVD other than in
>conjunction with low HDL, high TG, IR, abnormal BMI etc -- more or less
>metabolic syndrome. You can correct me on this if you wish, but I would need
>convincing.

Here's the thing about letting yourself off the hook if you don't officially
qualify for diagnosis with metabolic syndrome:

Ann Intern Med 1998 Apr 1;128(7):524-33

Metabolic risk factors worsen continuously across the spectrum of nondiabetic
glucose tolerance. The Framingham Offspring Study.

Meigs JB, Nathan DM, Wilson PW, Cupples LA, Singer DE
Massachusetts General Hospital, Harvard Medical School, Boston University
School of Public Health, 02114, USA. jmeigs@sol.mgh.harvard.edu

BACKGROUND: Categorical definitions for glucose intolerance imply that risk
thresholds exist, but metabolic risk for type 2 diabetes mellitus or
cardiovascular disease may increase continuously as glucose intolerance
increases. OBJECTIVE: To examine the distributions of the following metabolic
risk factors across the spectrum of glucose tolerance: overall and central
obesity, hypertension, low levels of high-density lipoprotein cholesterol, and
increased triglyceride and insulin levels. DESIGN: Cross-sectional analysis.
SETTING: The community-based Framingham Offspring Study. PARTICIPANTS: 2583
adults without previously diagnosed diabetes. MEASUREMENTS: Clinical data;
fasting glucose, insulin, and lipid levels; and glucose and insulin levels
taken 2 hours after oral challenge were collected from 1991 to 1993. Glucose
tolerance was determined by 1980 World Health Organization criteria. Patients
with normal glucose tolerance were categorized into quintiles of fasting
glucose. The distributions of each metabolic risk factor and the metabolic sum
of the six risk factors were assessed across seven categories from the lowest
quintile of normal fasting glucose level through impaired glucose tolerance and
previously undiagnosed diabetes. RESULTS: The mean age of patients was 54 years
(range, 26 to 82 years); 52.7% of patients were women. Glucose tolerance
testing found that 12.7% of patients had impaired glucose tolerance and 4.8%
had previously undiagnosed diabetes. Multivariable-adjusted mean measures of
risk factors and odds ratios for obesity, elevated waist-to-hip ratio,
hypertension, low levels of high-density lipoprotein cholesterol, elevated
triglyceride levels, and hyperinsulinemia showed continuous increases across
the spectrum of nondiabetic glucose tolerance. Although a threshold effect near
the upper range of nondiabetic glucose tolerance could not be ruled out for
triglyceride levels in men and for insulin levels 2 hours after oral challenge
in men and women, no other metabolic risk factors showed clear evidence of
thresholds for increased risk. CONCLUSIONS: Metabolic risk factors for type 2
diabetes mellitus and for cardiovascular disease worsen continuously across the
spectrum of glucose tolerance categories, beginning in the lowest quintiles of
normal fasting glucose level.

PMID: 9518396, UI: 98175274

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Blood Glucose Concentration Linked to>Cardiovascular Risk in Nondiabetic Men>
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WESTPORT,>CT (Reuters Health) Jan 04 - Increased glycated hemoglobin
(HbA1c)>concentrations are predictive of cardiovascular mortality among
all men,>not only those with diabetes, according to a report in the
British>Medical Journal for January 6.

Dr. Kay-Tee Khaw and colleagues, from>the University of Cambridge
School of Clinical Medicine, UK, collected>data on all-cause mortality
and cardiovascular mortality in 4662 men, 45>to 79 years of age, who
participated in the Norfolk UK cohort of the>European Prospective
Investigation into Cancer and Nutrition>(EPIC-Norfolk). At baseline,
from 1995 to 1997, HbA1c was measured and>the subjects were followed
until December 1999.

As expected, Dr.>Khaw's group found that diabetic men had increased
mortality for all>causes, cardiovascular disease and ischemic disease.
They also noted that>HbA1c concentrations were "continuously related to
subsequent all-cause,>cardiovascular, and ischemic mortality through
the whole population." The>lowest mortality rates were associated with
HbA1c concentrations below>5%.

Further, the group noted that a 1% increase in HbA1c was>associated
with a 28% increased risk of death, which was independent of>age, blood
pressure, cholesterol, body mass index and>smoking.

"Eighteen percent of the population excess mortality risk>associated
with a HbA1c concentration of 5% or more occurred in men with>diabetes,
but 82% occurred in men with concentrations of 5% to 6.9% (the>majority
of the population)," Dr. Khaw and colleagues point>out.

The researchers propose that an elevated concentrations of>HbA1c is a
marker for greater absolute risk among all men, and>"preventive
treatment with blood pressure- or cholesterol-lowering drugs>should be
considered in such patients."

They point out that if>the population of nondiabetic men was able to
lower its HbA1c>concentration by 0.1%, total mortality could be reduced
by 5%, and if the>concentration could be lowered by 0.2%, then total
mortality could be>reduced by 10% in this population. 

-- 
The only dietary intervention proven to lower these risks is lower carb.  
>I would suggest 'more complicated, less effective' but perhaps easier to 
>comply with for most people, eg, Mediterranean diet. For lower-carbers (if 
>you must <g>), Atkins is the wrong way to go. Something like South Beach 
>would be a much better option.
This is stunningly ignorant remark, suggesting no variation in individual
clinical needs.  Atkins is completely healthy, as much as South Beach. 
Different folks have different tolerances.  I remained severely IR and
hypoglycemic on the Zone, became hypothyroid on Atkins induction, and do best
on 50% fat, 30% protein, 20% carbs, for now.  Everyone's needs are different; 
making a sweeping recommendation as you just did is, well, dumb.
Susan
>
>Paul R
>
>
>---
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