Liver steatosis /serum iron / transferrin saturation / ferritin

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Date: 01/17/05 

Date: 17 Jan 2005 06:28:26 -0800

Rev Esp Enferm Dig. 2004 Dec;96(12):818-828. Related Articles, Links

Iron overload and genotype 3 are associated with liver steatosis in
chronic hepatitis C.

[Article in English, Spanish]

Fernandez Salazar L, Alvarez Gago L, Aller de la Fuente R, Orduna
Domingo A, Arranz Santos T, de la Calle Valverde F, Del Olmo Martin L,
de Luis Roman D, Gonzalez Hernandez J.

Servicio de Aparato Digestivo. Hospital Clinico Universitario.
Valladolid, Spain.

Objective: to determine epidemiological, biochemical, virological, and
histological factors associated with liver steatosis in chronic
hepatitis C. Subjects: the medical histories of 53 patients biopsied
for chronic hepatitis C diagnosis between June 2000 and December 2002
were retrospectively studied. Epidemiological, biochemical, and
virological data were collected. Patients with hepatitis B virus or
human immunodeficiency virus coinfection were excluded. Liver biopsy
specimens were reviewed and scored by one pathologist. Weight and
height were measured at liver biopsy time. The statistic association
between qualitative and quantitative variables and the presence of
liver steatosis was studied. Results: steatosis was identified in 52%
of biopsies. There was no statistic association with age, sex, method
of transmission, duration of infection, alcohol consumption, other
diseases, body mass index, glucose, triglycerides, cholesterol, AST,
ALT, GGT, alkaline phosphatase, bilirubin, or viral load. Liver
steatosis was associated with serum iron, transferrin saturation, and
ferritin. Genotype 3 was also associated with steatosis. Piecemeal
necrosis, hepatocellular injury, Kupffer cell hyperplasia, liver iron,
and portal fibrosis were also associated with steatosis. A multivariate
analysis showed that genotype 3, Kupffer cell hyperplasia, and liver
iron were associated with the presence of steatosis. Conclusions: liver
steatosis in chronic hepatitis C associates with genotype 3, Kupffer
cell hyperplasia, and iron overload. Hepatic steatosis also associates
with greater inflammation and fibrosis, and must be considered to
contribute to disease progression.

PMID: 15634182 [PubMed - as supplied by publisher]

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