Green Tea Extract Has Potential as Anti-Cancer Agent, According to UCLA Researchers

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Date: 15 Feb 2005 18:38:24 -0800

http://www.healthsentinel.com/news.php?event=news_print_list_item&id=615

"Green Tea Extract Has Potential as Anti-Cancer Agent, According to
UCLA Researchers", Medical News Today, February 15, 2005,
Link: http://www.medicalnewstoday.com/medicalnews.php?newsid=20075

A study on bladder cancer cells lines showed that green tea extract has
potential as an anti-cancer agent, proving for the first time that it
is able to target cancer cells while leaving healthy cells alone.

The study, published in the Feb. 15, 2005 issue of the peer-reviewed
journal Clinical Cancer Research, also uncovered more about how green
tea extract works to counteract the development of cancer, said JianYu
Rao, a Jonsson Cancer Center member, an associate professor of
pathology and laboratory medicine and the study's senior author.

"Our study adds a new dimension in understanding the mechanisms of
green tea extract," Rao said. "If we knew exactly how it works to
inhibit the development of cancer, we could figure out more precisely
which bladder cancer patients might benefit from taking it."

Numerous epidemiologic and animal studies have suggested that green tea
extract provides strong anti-cancer effects in several human cancers,
including bladder cancer. It has been shown to induce death in cancer
cells, as well as inhibiting the development of an independent blood
supply that cancers develop so they can grow and spread.

In the UCLA study, which brought together researchers from UCLA's
Jonsson Cancer Center, School of Public Health, Center for Human
Nutrition and the departments of Pathology and Laboratory Medicine,
Surgery, Urology and Epidemiology, scientists were able to show that
green tea extract interrupts a process that is crucial in allowing
bladder cancer to become invasive and spread to other areas of the
body.

Green tea extract affects actin remodeling, an event associated with
cell movement. When a human moves, the muscles and skeletal structure
operate together to facilitate that movement. For cancer to grow and
spread, the malignant cells must be able to move. The cell movement
depends on actin remodeling, which is carefully regulated by complex
signaling pathways, including the Rho pathway. When actin remodeling is
activated, the cancer cells can move and invade other healthy cells and
eventually other organs. By inducing Rho signaling, the green tea
extract made the cancer cells more mature and made them bind together
more closely - a process called cell adhesion. Both the maturity of the
cells and the adhesion inhibited the mobility of the cancer cells, Rao
said.

"In effect, the green tea extract may keep the cancer cells confined
and localized, where they are easier to treat and the prognosis is
better," Rao said. " Cancer cells are invasive and green tea extract
interrupts the invasive process of the cancer."

Bladder cancer is the fifth most common cancer in the United States,
with about 56,000 new cases diagnosed each year. About half of all
bladder cancers are believed to be related to cigarette smoking.
Without a reliable, non-invasive way to diagnose the disease, bladder
cancer can be difficult to detect in the early, most treatable stages.
When not found early, the tumors can be aggressive, and more than half
of patients with advanced cancers experience recurrences.

UCLA researchers currently are seeking hundreds of former smokers who
have had bladder cancer for a clinical trial studying whether green tea
extract prevents recurrence - one of the first studies in the country
to test the agent on cancer patients. The study is part of a
comprehensive program funded by the National Cancer Institute and
designed to prevent the recurrence and progression of smoking-related
bladder cancer. In addition to the trial, the program seeks to develop
new biomarker tests to help predict who will get bladder cancer,
discover the molecular profile of the disease to identify those most at
risk and create a tumor bank to aid research. Volunteers interested in
participating in the study should call (310) 825-4415.

Rao cautioned that his study was conducted in a carefully controlled
cell line environment and that more research needs to be done to
discover exactly how green tea extract functions as a cancer fighter.
The next phase of his research will analyze urine from bladder cancer
patients to determine which subset of patients would benefit most from
taking green tea extract. Researchers will be looking for specific
biomarkers associated with actin remodeling and activation of the Rho
signaling pathway.

"We're hoping the results from these studies will tell us who will best
benefit from the agent," Rao said, adding that the basic research he is
doing and the clinical trial on bladder cancer patients will provide
scientists with vital information from both ends the research
continuum, an example of bench- to- bedside-and-back-again science.

"I think this publication further supports the potential role of green
tea in the prevention and treatment of bladder cancer," said Dr. Robert
Figlin, a UCLA professor of hematology/oncology and urology and a
principal investigator for the human studies. "In the end, both studies
will help us achieve our goal - to decrease bladder cancer occurrence
and develop molecular profiles that tell us who is most at risk."

UCLA's Jonsson Comprehensive Cancer Center is composed of more than 240
cancer researchers and clinicians engaged in cancer research,
prevention, detection, control and education. One of the nation's
largest comprehensive cancer centers, the JCCC is dedicated to
promoting cancer research and applying the results to clinical
situations. In 2004, the Jonsson Cancer Center was named the best
cancer center in the western United States by U.S. News & World Report,
a ranking it has held for five consecutive years.

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