Re: Cholesterol's Function?

From: Mirek Fidler (cxl_at_volny.cz)
Date: 03/25/05 

Date: Fri, 25 Mar 2005 23:54:20 +0100

>>You you want to base your claims on facts, try first to feed data of
>>this person (LDL 187, HDL 91, TG 51) to some of risk calculators that
>>are based on models using actual data. To my knowledge, this profile is
>>far from atherogenic.
>>
>>Mirek
>
>
> There is no mention of other risk factors to make an LDL goal. A 187 is far
> from good.

HDL 91 and TG 51 is far from bad. Balance is what is really predictive.

If he is 50 years old, non-smoker, no DM, BP < 120, his profile
indicates same risk (2%) as e.g. one with HDL 50, LDL 120, TG 120 (which
would be considered absolutely OK without further risk factors).

> With family
> history, diabetes or if he had a recent MI then it is not good.

That is true.

> There is no mention of age as with increasing age it gets more fuzzy on
> benefits overall as predictors of CAD.

Hm, I guess opposite is true also. I think best benefit is somewhere
between 40-60 years. Before 40, CAD event is too unlikely, after 60 it
is too fuzzy as you have said.

> There is differences on male vs female also so many factors involved before
> one can make an assessment and say that "profile is far from atherogenic".

This specific profile is low-risk (that is, less than 10% for 10 years
prediction) both for male and female for all ages.

Of course, little we know about other risk factors (but based on low TG
     DM or MetS diagnosis is unlikely). Anyway given this profile alone,
risk is definitely low (<10% is considered low AFAIK).

Mirek

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