Re: N-acetylcysteine / colitis

From: Ken.W (phosgate_at_telus.net)
Date: 03/28/05 

Date: Mon, 28 Mar 2005 16:29:35 GMT

Thats not surprising that berkely doesn't have anything on it.I bet they
don't have anything on olive oil extract either. I've copied and paste a bit
of info on it for you John.
If you had read the Book "the comparitive guide to nutritonal supplements"
you will find that it was a key element in any worthwhile supplement
according to
the nutritional experts he based his comparison too.

a.. N-acetyl-L-cysteine has been used in the treatment of acetaminophen
overdose, chronic lung disorders; HIV (where it has been shown to enhance
human T-cell function and survival), and hepatitis B (where is has been
shown to inhibit hepatitis B replication). It has been further used as a
chemopreventative agent in cancer research.
a..
a.. 1 Lehninger AL. Biochemistry. Worth Publishers, Inc., New York. 1104
pp. 1975.
2 Rivlin RS. Riboflavin. Pp. 167-173. In. EE Ziegler and LJ Filer (eds.)
Present Knowledge in Nutrition. ILSI Press, Washington, DC.
3 Lavender OA and RF Burk. Selenium. Pp. 320-328. In. EE Ziegler and LJ
Filer (eds.) Present Knowledge in Nutrition. ILSI Press, Washington, DC.
4 Lomaestro BM and M Malone. Glutathione in health and disease:
pharmacotherapeutic issues. Annals of Pharmacotherapy (1995) 29: 1263-73
5 Aw TY, Wierzbicka G, Jones DP. Oral glutathione increases tissue
glutathione in vivo. Chem Biol Interact 1991;80:89-97.
6 Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH. Efficacy of oral
N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the
national multicenter studyN Engl J Med Dec 15 1988; 319(24):1557-62.
7 Cayota A, Vuillier F, Gonzalez G, Dighiero G. In vitro antioxidant
treatment recovers proliferative responses of anergic CD4+ lymphocytes from
human immunodeficiency virus-infected individuals. Blood 1996 Jun 1;
87(11):4746-53.
8 Weiss L, Hildt E, Hofschneider PH. Anti-hepatitis B virus activity of
N-acetyl-L-cysteine (NAC): new aspects of a well-established drug. Antiviral
Res 1996 Aug;32(1):43-53.
9 Ho YS; Lee HM; Mou TC; Wang YJ; Lin JK . Suppression of nitric
oxide-induced apoptosis by N-acetyl-L-cysteine through modulation of
glutathione, bcl-2, and bax protein levels. Mol Carcinog1997 Jun;
19(2):101-13.
10 Jones DP, Coates RJ, Flagg EW, Eley JW, Block G, Greenberg RS, et al.
Glutathione in foods listed in the National Cancer Institutes health habits
and history food frequency questionnaire. Nutr Cancer 1992;17:57-75.
11 Kaplowitz N, AW TY, Ookhtens M. The regulation of hepatic glutathione.
Ann Rev Pharmacol Toxicol 1985;25:715-44.

a..
a..
a..
a.. "John H" <john@rhubarb.org> wrote in message
news:4247d0ee@clear.net.nz...
> This is the first time I have heard of it, but I notice a lot of
> supplement makers sell it on their web sites. I don't recall it at the
> Chemist shop.I searched the UC Berkely site and nothing came up.
> John
> <ironjustice@aol.com> wrote in message
> news:1111954901.926211.288620@g14g2000cwa.googlegroups.com...
>>J Int Med Res. 2005 Mar-Apr;33(2):196-206. Related Articles, Links
>>
>>
>> Effects of N-acetylcysteine treatment on oxidative stress in acetic
>> acid-induced experimental colitis in rats.
>>
>> Akgun E, Caliskan C, Celik HA, Ozutemiz AO, Tuncyurek M, Aydin HH.
>>
>> Department of General Surgery, Ege University School of Medicine,
>> Bornova, Izmir, Turkey. eakgun@med.ege.edu.tr
>>
>> We assessed the possible protective effects of N-acetylcysteine (NAC)
>> against toxic damage in the rat colon. Two doses of NAC (20 mg/kg and
>> 100 mg/kg) given for 2 days and 7 days after acetic acid administration
>> (to induce colitis) were tested. NAC was dissolved in saline and
>> administered locally (intracolonic), systemically (intraperitoneal) or
>> in a combination (intracolonic and intraperitoneal). Several
>> parameters, including macroscopic and histopathological scores and
>> myeloperoxidase, glutathione and nitric oxide concentrations were
>> measured using standard assay procedures. Treatment with 100 mg/kg NAC
>> for 7 days significantly decreased tissue myeloperoxidase, glutathione
>> and nitric oxide concentrations. The 20 mg/kg dose had no protective
>> effects. The data indicate that NAC substantially reduced the degree of
>> colonic injury, probably by regulating free radical production and
>> inhibiting inflammation. It may, therefore, have a role in the
>> treatment of inflammatory bowel disease.
>>
>> PMID: 15790131 [PubMed - in process]
>>
>> --------------------------------------------------------------------------------
>>
>> Who loves ya.
>> Tom
>>
>> Jesus Was A Vegetarian!
>> http://herbivore.7h.com
>>
>
>

Relevant Pages

  • Re: N-acetylcysteine / colitis
    ... Filer Present Knowledge in Nutrition. ... Glutathione in health and disease: ... N-acetylcysteine in the treatment of acetaminophen overdose. ... N-acetyl-L-cysteine: new aspects of a well-established drug. ...
    (sci.med)
  • Re: N-acetylcysteine / colitis
    ... " The comparitive guide to nutritonal supplements" has it not?? ... >> chemopreventative agent in cancer research. ... >> Filer Present Knowledge in Nutrition. ... Oral glutathione increases tissue ...
    (sci.med.nutrition)
  • Re: N-acetylcysteine / colitis
    ... " The comparitive guide to nutritonal supplements" has it not?? ... >> chemopreventative agent in cancer research. ... >> Filer Present Knowledge in Nutrition. ... Oral glutathione increases tissue ...
    (sci.med)