metastudy: dairy / ovarian cancer risk

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International Journal of Cancer, 28 Jul 2005

Milk, milk products and lactose intake and ovarian cancer risk: A
meta-analysis of epidemiological studies
Susanna C. Larsson *, Nicola Orsini, Alicja Wolk
Division of Nutritional Epidemiology, The National Institute of
Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

[Funded by:]
Swedish Cancer Foundation

[Abstract]
It has been proposed, on the basis of animal models and ecological studies,
that consumption or metabolism of dairy sugar may increase the risk of
ovarian cancer. Case-control and cohort studies of the association between
lactose and dairy food consumption and ovarian cancer risk, however, have
yielded varied findings. We summarized the available literature on this
topic using a meta-analytic approach. Random-effects models were used to
estimate the summary relative risks (RRsummary). A linear regression
analysis of the natural logarithm of the RR was carried out to assess a
possible dose-response relationship between lactose intake and ovarian
cancer risk. Eighteen case-control and 3 prospective cohort studies were
eligible for inclusion in the meta-analysis. The findings of case-control
studies were heterogeneous, and, except for whole milk (RRsummary for
highest vs. lowest category = 1.27, 95% confidence interval [CI] =
0.97-1.68), do not provide evidence of positive associations between dairy
food and lactose intakes with risk of ovarian cancer. In contrast, the 3
cohort studies are consistent and show significant positive associations
between intakes of total dairy foods, low-fat milk, and lactose and risk of
ovarian cancer. The RRsummary for a daily increase of 10 g in lactose intake
(the approximate amount in 1 glass of milk) was 1.13 (95% CI = 1.05-1.22)
for cohort studies. In conclusion, prospective cohort studies, but not
case-control studies, support the hypothesis that high intakes of dairy
foods and lactose may increase the risk of ovarian cancer.
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please note that I do not serve any interest in the dairy discussion here,
I am neither a dairy farmer nor a dairy hater.


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Relevant Pages

  • Milk link to ovarian cancer risk
    ... "Milk link to ovarian cancer risk", BBC News, November 29, 2004, ... Consuming large amounts of milk may increase the risk of developing ... Diet element unclear ...
    (sci.med.diseases.cancer)
  • Re: Milk link to ovarian cancer risk
    ... > Consuming large amounts of milk may increase the risk of developing ... of whom 125 had serious ovarian cancer. ... > risk of those who did not consume it at all, or only in small amounts. ...
    (sci.med.diseases.cancer)
  • Re: The cereal and milk test, or its not fun to be proven right
    ... Either high cortisol or insulin receptor defect or very high carb diets promote PCOS and ovarian cancer. ... PCOS, a precursor condition to ovarian cancer risk elevation is typically treated with a low carb diet, with or without metformin. ...
    (alt.support.diabetes)
  • Gingko May Prevent Ovarian Cancer
    ... demonstrates that ginkgo may help lower a woman's risk of developing ... 668 ovarian cancer cases and 720 healthy, matched controls, women who ... 60 percent lower risk of ovarian cancer. ...
    (sci.med.nutrition)
  • Gingko May Prevent Ovarian Cancer
    ... demonstrates that ginkgo may help lower a woman's risk of developing ... 668 ovarian cancer cases and 720 healthy, matched controls, women who ... 60 percent lower risk of ovarian cancer. ...
    (misc.health.alternative)