IFN-alpha and ribavirin causes decline in serum iron and ferritin
- From: "ironjustice@xxxxxxx" <ironjustice@xxxxxxx>
- Date: 17 Sep 2005 04:26:10 -0700
This article gives credence to the hypothesis that the current
treatment used in hepatitis C .. IS .. simply .. glorified ..
bloodletting .. chemical bloodletting.
Ribavarin causes hemolyis / destruction of red blood cells .. and
interferon is an iron binder.
Alterations of soluble transferrin receptor level in children with
chronic hepatitis C during treatment with recombinant interferon-alpha
and ribavirin.
Mozer-Lisewska I, Mania A, Kowala-Piaskowska A, Figlerowicz M,
Sluzewski W
Hepatol Res. 2005 Sep 12;
INTRODUCTION:: Hepatic iron stores in patients with chronic hepatitis C
(CHC) may accelerate the progression to liver cirrhosis and
hepatocellular carcinoma. Detection of soluble transferrin receptor
(sTfR) allows for quantitative evaluation of intracellular iron stores,
especially under circumstances of chronic inflammatory state, as CHC.
OBJECTIVE:: The aim of this study was to evaluate the concentration of
sTfR as an indicator of intracellular iron stores in relation to serum
iron management parameters in children with CHC and potential influence
of treatment with IFN-alpha and ribavirin. MATERIAL AND METHODS::
Fifteen children with diagnosed CHC were enrolled into the study, age
range 6-17.5 years (mean 11.17+/-3.86 years), 11 boys and 4 girls.
Children were treated with IFN-alpha (3MU/M(2) s.c. three times a week)
and ribavirin (15mg/kg p.o. daily) for 12 months. sTfR level was
detected by latex test N Latex sTfR (DADE Behring). RESULTS::
Observation after 16 weeks of the treatment revealed significant
increase of sTfR level (sTfRI=1.27mg/dl versus sTfRII=1.57mg/dl;
p=0.002) and serum Tf (TfI=190.98+/-61.23mg/dl versus
TfII=232.53+/-53.64mg/dl; p=0.019) with the decline in serum iron (Iron
I=138.72+/-65.91 versus Iron II=104.98+/-22.12; p=0.049) and ferritin
(Ferritin I=240.35+/-125.43mg/dl versus Ferritin
II=145.65+/-78.87mg/dl; p=0.022). Patients with viral response to
treatment developed higher, although not significant, sTfRII levels
than nonresponders. CONCLUSIONS:: Combined therapy with IFN-alpha and
ribavirin causes an increase in sTfR level with decline in serum iron
and ferritin, revealing intracellular reduction of iron stores
depending on the result of treatment.
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