At last, a comprehensive review study on taking vitamin E vs. neurodegenerative disorders
- From: soowhatdouthink@xxxxxxxxxxx
- Date: 22 Nov 2005 08:02:39 -0800
For sure will ruffle some feathers here;-).
Arbor
Ann Pharmacother. 2005 Nov 15; [Epub ahead of print]
Vitamin E Supplementation in Alzheimer's Disease, Parkinson's Disease,
Tardive Dyskinesia, and Cataract: Part 2 (December).
Pham DQ, Plakogiannis R.
Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long
Island University, Brooklyn, NY; Internal Medicine Pharmacotherapy
Specialist, Kings County Hospital Center, Brooklyn.
OBJECTIVE: To review clinical trials evaluating the safety and efficacy
of vitamin E supplementation in Alzheimer's disease, Parkinson's
disease, tardive dyskinesia, and cataract. DATA SOURCES: Using the MeSH
terms alpha-tocopherol, tocopherols, vitamin E, Parkinson disease,
tardive dyskinesia, Alzheimer disease, cataract, and clinical trials, a
literature review was conducted to identify peer-reviewed articles in
MEDLINE (1966-July 2005). STUDY SELECTION AND DATA EXTRACTION:
Published materials including original research, review articles, and
meta-analyses were reviewed. Only English-language articles and trials
that included vitamin E alone or in combination with other vitamins or
minerals were reviewed. Emphasis was placed on prospective, randomized,
double-blind, placebo-controlled clinical trials. DATA SYNTHESIS: The
clinical studies demonstrated contradicting results regarding the
benefits of vitamin E in Parkinson's disease, tardive dyskinesia, and
cataract. The study reviewed for Alzheimer's disease seemed to show
benefit when vitamin E was used; however, the statistical methods
employed are questionable. There is enough evidence from large,
well-designed studies to discourage the use of vitamin E in Parkinson's
disease, cataract, and Alzheimer's disease. We recommend that vitamin E
be considered a treatment option in patients with tardive dyskinesia
only if they are newly diagnosed. CONCLUSIONS: We encourage patients to
supplement with vitamin E-rich foods. The use of a daily multivitamin,
which usually contains 30 IU of alpha-tocopherol, may be beneficial;
however, we discourage individual vitamin E supplements that usually
contain 400 IU of alpha-tocopherol.
PMID: 16288072 [PubMed - as supplied by publisher]
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