Inhibiting iron intake
- From: "ironjustice@xxxxxxx" <ironjustice@xxxxxxx>
- Date: 10 Jan 2006 08:45:48 -0800
Inhibition of iron uptake by phytic acid, tannic acid, and ZnCl2:
studies using an in vitro digestion/Caco-2 cell model.
Glahn RP, Wortley GM, South PK, Miller DD
J Agric Food Chem. 2002 Jan 16; 50(2): 390-5
The objective of this study was to document the effects of phytic acid,
tannic acid, and zinc on iron uptake in an in vitro digestion/Caco-2
cell culture model. The effects of phytic acid and tannic acid on iron
uptake were measured at increasing molar ratios of FeCl3 to phytic acid
or tannic acid. Maximal inhibition of iron uptake by phytic acid
occurred at a 1:10 ratio of Fe to phytic acid. Dialyzable Fe decreased
with a low Fe to phytic acid ratio but increased with Fe:phytic acid
ratios greater than 1:3 indicating that more iron was soluble at higher
phytic acid levels but less available. As in human studies, heme iron
was less inhibited by phytic acid than nonheme iron. Tannic acid was a
more potent inhibitor of nonheme iron uptake, as maximal inhibition
(97.5%) of iron uptake occurred at a ratio of 1:1 or less. The addition
of ZnCl2 to the digest at ratios of 1:0.5 and 1:1 decreased iron uptake
by 57 and 80%, respectively. Overall, the results agree qualitatively
with studies in humans and demonstrate the relative effects of these
compounds on iron uptake in this model system. This study provides key
information for determining iron availability under more complex meal
conditions.
-------------------------------------
http://www.sciencedaily.com/releases/2002/12/021213062321.htm
American Chemical Society
Date:
12/13/2002
Too Much Grape Juice Could Cause Iron Deficiency
The same antioxidant compounds in dark grape juice that are noted for
their
health benefits in fighting heart disease may have a downside,
according to new
research in the Journal of Agricultural and Food Chemistry. In cell
studies,
scientists with the U.S. Department of Agriculture and Cornell
University found
that polyphenols in purple (also called red) grape juice can inhibit
the uptake
of iron, which could increase the risk of iron-deficiency anemia.
-------------------------------------
http://tinyurl.com/8jp9m
The "grape cure," whereby only grapes or grape juice are taken for
several days or weeks, is very beneficial as an aid in overcoming many
chronic diseases.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
.
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