Re: (Oxydized) LDL not Mr. Bad Guy?

Arachidonic is much more biochemically active than Mead acid, which is
why some like Enig say that it is a "filler" and ineffective. Those
who attack me want it both ways. If it is so much less biochemically
active (as all agree with, including myself, except, apparently
MattLB), then it will not cause the kinds of problems AA does.
Moreover, I am suggesting that the body should produce Mead acid on its
own, rather than getting it from the diet. In this way, you rely on
the intelligence of cells to refrain from producing something dangerous
to themselves. The only way you are going to get AA in your cells is
if you eat a lot of PUFAs, which the evidence suggests is a terrible
idea.

I don't know how MattLB thinks the oxLDL is going to get to the artery
wall if it is not in ciruculation first, though it's true that the
antibodies could very well be a red herring here. What MattLB is
talking about is not the first stage of "coronary heart disease" -
inflammation will occur first, and the oxLDL is acting as an irritant
that stresses cells, which then signal for the "immune system." Then
the macrophages come in and are rendered dysfunctional, creating what
one scientist called "death zones" in the artery walls. This is when
plaque formation begins.

It is important to point out that to have so much oxLDL as to cause
this problem, your diet has to be really bad: full of PUFAs, meat
cooked while exposed to air, and few antioxidant-rich foods. The
"heart disease epidemic" began when more food items were refined to a
point that destroyed much of the antioxidants. People were also eating
food like fried meats in large amounts, without antioxidant-rich foods
(meat and potatoes do not contain much in the way of antioxidants, for
example). Such an "epidemic" happened in England in the late 1900s,
when they began using powdered dairy, which is very rich in oxidized
cholesterol. In the USA, it happened after WW II, for similar reasons.
Refined oils, high in PUFAs, then became common by the 1960s, and the
"epidemic" reached a peak, though it's very high now, considering how
few people died of "heart disease" in the USA prior to 1940 or
thereabouts. Since the "epidemic" killed many men in "middle age,"
this should have also happened prior to 1940, and thus the only
explanation that makes sense in this dietary one.

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