Re: (Oxydized) LDL not Mr. Bad Guy?

On 24 Feb 2006 06:18:10 -0800, "MattLB" <mattlb@xxxxxxxxxxxxx> wrote:

In an LDL particle it's irrelevant whether it's AA or Mead. They're
both PUFA and both do nothing biochemical, because they have to be in
cells to do that.

Nah, not quite correct. Isoketals may still be formed and do harm even
outside a cell, and chances are even increased that arachidonic acid
will meet such a non-enzymatically fate outside the cell, where oxygen
molecules may react with the cyclic form of it.

Most probably, many physiological/biochemical effects of arachidonate
not explainable by eicosanoids are due to the forming of isoketals and
alike :-(

(See isoketals, isoneurals and isofurans on PubMed, or do search for
isolevuglandins and levuglandins.

.