Re: High cholesterol protective against infection?

On Thu, 3 Aug 2006 23:46:48 +0300, "Juhana Harju"
<shantigiriorama@xxxxxxxxx> wrote:

Matti Narkia wrote:
: On Thu, 3 Aug 2006 22:34:23 +0300, "Juhana Harju"
: <shantigiriorama@xxxxxxxxx> wrote:
:
:: Matti Narkia wrote:
::: On 3 Aug 2006 09:52:02 -0700, "Ron Peterson" <ron@xxxxxxxxxxxxxx>
::: wrote:
:::: Susan wrote:
::::
::::: Lipopolysaccharide, or endotoxin, the main pathogenic factor of
::::: Gram-negative bacteria, binds rapidly to lipoproteins,6 mainly
::::: LDL,7 and lipoprotein-bound endotoxin is unable to activate the
::::: secretion of various cytokines by monocytes in vitro.6,7,10 Also,
::::: Staphylococcus aureus {alpha}-toxin, a toxin produced by most
::::: pathogenic Staphylococcus strains and causing damage to a wide
::::: variety of cells, is bound and almost totally inactivated by human
::::: serum and purified LDL, as estimated by haemolytic titration.3"
::::
:::: Is there an hypothesis that bacteria are one of the main causes of
:::: cardiovascular disease?
::::
::: There is a hypothesis about inflammation being a causative factor.
::: Infection is one of the causes of inflammation. Infection may be
::: caused by virus, bacteria, fungi or any other pathogens foreign to
::: our bodies. Low grade systemic inflammation can persist even when
::: there are no foreign pathogens, the cause can also be internal.
:::
:::: If so, would that explain why Italy has a lower incidence of
:::: cardiovascular disease because of their overuse of antibiotics?
:::
::: Perhaps life style factors such as Mediterranean diet could have
::: greater effect, IMHO, although Italian diet is probably not as good
::: as Cretan traditional Mediterranean diet. I'm not familiar with the
::: Italian overweight and obesity statistics, but if they are better
::: than average, that could be part of the reason.
::
:: hs-CRP is a inflammatory marker and to my knowledge the largest
:: reductions in hs-CRP has been achieved by the low fat Pritikin diet
:: (combined with exercise).
:
: I doubt that

According to this Pritikin site CRP plunged 45 % in average.

http://www.pritikinca.com/benefits/womensHealth/womensHealth_HeartDisease.shtml

Corresponding Medline abstract:

Metabolism. 2004 Mar;53(3):377-81.
Effect of diet and exercise intervention on inflammatory and adhesion
molecules in postmenopausal women on hormone replacement therapy and at risk
for coronary artery disease.
Wegge JK, Roberts CK, Ngo TH, Barnard RJ.
Department of Physiological Science, University of California, Los Angeles,
CA 90095, USA.

A small non-randomized uncontrolled study. Do I need to say more? Yes:
Effects of exercise cannot be separated from the effects of the diet.
Another diet, say a well designed healthy low carb including
anti-inflammatory foods could have fared better with exercise than
Pritikins protocol. We will never know, if they are not compared in
the same randomized controllod study.


--
Matti Narkia
.

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