Re: The lipid hypothesis

On Wed, 24 Jan 2007 02:34:17 GMT, Jim Chinnis wrote:

I have searched for evidence that saturated fat increases CHD risk without
finding good evidence. I have gotten copies of most of the cited (old)
studies.


According to this review article (2004), the association between sat fats
and CHD or stroke is "elusive" from an epidemiological point of view.


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15294485&query_hl=1&itool=pubmed_docsum
Asia Pac J Clin Nutr. 2004 Aug;13(Suppl):S22.
Dietary fat quality: a nutritional epidemiologist's view.
[...]
| Between-population ecologic studies have demonstrated an association
| between intake of fat, specifically saturated fat and total cholesterol
| and coronary heart disease (CHD) mortality. However, results are
| inconsistent from within-population cohort studies. Likewise, the
| association between intake of total fat and saturated fat and with risk
| for stroke remains elusive.
[...]


Metabolic studies -they also say- showed a link between sat fats and
cholesterol levels but different SFAs have different effects.

| In metabolic studies different classes of saturated fatty acids (SFA)
| have different effects on plasma lipid and lipoprotein levels.
| Specifically, SFA with 12-16 carbon atoms tend to increase plasma total
| and LDL-chol levels, whereas stearic acid does not have a
| cholesterol-raising effect, but may lower HDL-chol especially in women,
| and increase Lp(a) concentration. Among the cholesterol-raising SFA,
| myristic acid appears to be more potent than lauric acid or palmitic
| acid, but the data are not entirely consistent.
[...]
.

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