Krebs Cycle Metabolites / Mystery!
- From: "Executive Crackhead" <CrackheadMillionaire@xxxxxxxxx>
- Date: 29 Mar 2007 10:30:13 -0700
Hello friends -
I'm trying to figure out how to interpret a set of OAT values in
regards to the Krebs cycle.
Results showed very low levels of citric acid and very high levels of
3-oxyglutaric acid. Normal range for succinic and fumaric acid. I
took this to mean that something (?) was keeping the Krebs cycle from
kicking off. It would seem the limiting factor isn't availabilty of
Acetl coA as very high levels of 3-hydroxybutyric, and acetoacetic
acid were recorded. This, I have read, may indicate ketosis is
occurring.
The subject is on a diet free of all complex carbohydrates, but
receives plenty of simple carbs in the form of fruits and to a lesser
extent, vegetables.
The doctor isn't worried about the values described here, but I'm not
so sure. He believes that mitochondrial dysfunction is the cause of
these values. (Mitochondrial dysfunction is known to occur in some
instances in subjects with the same diagnosis).
My interpretation was I thought the Krebs cycle was all about
providing energy for the mitochondria to use. If we are low in citric
acid, how are we generating ATP to be spent; i.e., could mitochondrial
dysfunction be related to a lack of ATP resulting from a very low
amount of citric acid available to kick start the cycle?
Does anyone have any insight? I'd also be interested in understanding
if there are other diagnostic options available to me to evaluate at a
finer level of detail the sub processes involved to try to determine
where things are going wrong.
Thanks!
- ec
.
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