Re: Fructose and heart disease

On Jun 28, 9:53 pm, monty1...@xxxxxxxxx wrote:
Risk factor and marker (indirect) are used to mean the exact same
thing,

No they aren't. You're using muddled terminology again. A risk factor
is something that causes (directly or indirectly) a problem and the
more of it you have the greater the risk of the problem occurring. A
marker is something that indicates a problem is already present i.e.
it's a recognisable consequence of the problem, not a cause.

for example:

[Fibrinogen as a cardiovascular risk factor--marker or causal factor?]

Yes. Is it a marker or a causal factor? One or the other.

However, the more important point is that it's not that a person has
some LDL molecules with PUFAs in them, but the amount of PUFAs. The
more PUFAs, the more likely the LDL is to become dsyfunctional.

How many PUFA in an LDL particle is required then?

As many scientists have pointed out: ..."small dense LDL is more
readily available to be oxidized. In addition, small dense LDL
particles are themselves more susceptible to oxidation..."

So you've changed your tune about the lipid profile just being
indirect markers have you? That's good, because small dense LDL is a
causitive agent and therefore a risk factor. The reason it's worse is
the reason LDL is bad in the first place - long survival time in the
blood so a greater risk of ending up in the artery wall. The amount of
PUFA is a side-issue since in the blood LDL causes no harm and doesn't
get oxidised.

The key is to avoid oxidative stress, which is something that is very
difficult to do if you have arachidonic acid in your cells.

You still can't grasp that AA is released as a deliberate signal
molecule can you?

evidence is plentiful on this point.

So you say, but you can't provide reasons or mechanisms so it's just a
faith position.

If you find that it causes you
cognitive dissonance for some reason, that is another matter - one
that is of little interest to me.

Anything beyond your own version of biology seems to have little
interest to you, partly because your world-view would be shattered if
you acknowledged it.

MattLB

.

Relevant Pages

  • Re: Fructose and heart disease
    ... more of it you have the greater the risk of the problem occurring. ... marker is something that indicates a problem is already present i.e. ... some LDL molecules with PUFAs in them, ...
    (sci.med.nutrition)
  • Re: Lowering Carbs Improves Cholesterol
    ... Jim Chinnis wrote: ... even when accompianied by a decrease in LDL ... "The burden of proof for any newly proposed risk factor is that it must ... The triglycerides will have skyrocketed. ...
    (sci.med.nutrition)
  • Re: CRP Theory: Cleeman and conflict of interests
    ... >> people with known CHD or CHD equivalents). ... >> was suggested for normal adults or even high risk adults without CHD. ... I also wonder why they are still speaking about LDL only as studies have ... Individuals with similar LDL/HDL ratios had ...
    (sci.med.cardiology)
  • Re: Lowering Carbs Improves Cholesterol
    ... Jim Chinnis wrote: ... even when accompianied by a decrease in LDL ... "The burden of proof for any newly proposed risk factor is that it must ... The triglycerides will have skyrocketed. ...
    (sci.med.nutrition)
  • Re: Should a women get a statin
    ... First I agree that fish oil is a safe option to statins and probaby ... Greater benefit because of lack of risk? ... LDL, making use of such criteria for guiding therapy in high-risk ... significant in meta-analyses of populations of low SES. ...
    (sci.med.cardiology)