Coffee And Doughnuts Protective Against Alzheimer's Disease

Neurol Res. 2007 Jan;29(1):91-5.
Alzheimer's disease and coffee: a quantitative review.
Barranco Quintana JL, Allam MF, Serrano Del Castillo A,
Fernandez-Crehuet Navajas R.
Department of Preventive Medicine and Public Health,
Faculty of Medicine, University of Cordoba, Cordoba, Spain.

PURPOSE: To estimate the pooled risk of coffee consumption
for Alzheimer's disease (AD).

MATERIAL AND METHODS: We have reviewed all observational
studies that evaluated the association between AD risk
and coffee consumption. Four studies were identified: two
case-control studies and two cohorts. These studies were
carried out between 1990 and 2002.

RESULTS: There was an obvious protective effect of coffee
consumption in the pooled estimate [risk estimate: 0.73
(95% confidence interval: 0.58-0.92)]. However, the
homogeneity test was highly significant (p<0.01),
indicating heterogeneity across the pooled studies.
Pooled analysis applying the random effect model was
0.79 with 95% confidence interval overlapping unity (95%
confidence interval: 0.46-1.36). Three studies assessed
coffee consumption by interview questionnaire. The risk
of AD in coffee consumers versus non-consumers in
studies that used interview questionnaire had a pooled
risk estimate of 0.70 with 95% confidence interval
0.55-0.90.

CONCLUSION: Although our pooled estimates show that
coffee consumption is inversely associated with the risk
of AD, the four studies had heterogeneous methodologies
and results. Further prospective studies evaluating the
association between coffee consumption and AD are
strongly needed.
.

Relevant Pages