Benefits of omega 3 for Type I Diabetes

http://jama.ama-assn.org/cgi/content/abstract/298/12/1420 says
Omega-3 Polyunsaturated Fatty Acid Intake and Islet Autoimmunity in
Children at Increased Risk for Type 1 Diabetes
Jill M. Norris, MPH, PhD; Xiang Yin, MD, MS; Molly M. Lamb, BA;
Katherine Barriga, MSPH; Jennifer Seifert, BS; Michelle Hoffman, RN;
Heather D. Orton, MS; Anna E. Barón, PhD; Michael Clare-Salzler, MD;
H. Peter Chase, MD; Nancy J. Szabo, PhD; Henry Erlich, MD, PhD; George
S. Eisenbarth, MD, PhD; Marian Rewers, MD, PhD

JAMA. 2007;298:1420-1428.

Context Cod liver oil supplements in infancy have been associated
with a decreased risk of type 1 diabetes mellitus in a retrospective
study.

Objective To examine whether intakes of omega-3 and omega-6 fatty
acids are associated with the development of islet autoimmunity (IA)
in children.

Design, Setting, and Participants A longitudinal, observational
study, the Diabetes Autoimmunity Study in the Young (DAISY), conducted
in Denver, Colorado, between January 1994 and November 2006, of 1770
children at increased risk for type 1 diabetes, defined as either
possession of a high diabetes risk HLA genotype or having a sibling or
parent with type 1 diabetes. The mean age at follow-up was 6.2 years.
Islet autoimmunity was assessed in association with reported dietary
intake of polyunsaturated fatty acids starting at age 1 year. A case-
cohort study (N = 244) was also conducted in which risk of IA by
polyunsaturated fatty acid content of erythrocyte membranes (as a
percentage of total lipids) was examined.

Main Outcome Measure Risk of IA, defined as being positive for
insulin, glutamic acid decarboxylase, or insulinoma-associated
antigen-2 autoantibodies on 2 consecutive visits and still
autoantibody positive or having diabetes at last follow-up visit.

Results Fifty-eight children developed IA. Adjusting for HLA
genotype, family history of type 1 diabetes, caloric intake, and
omega-6 fatty acid intake, omega-3 fatty acid intake was inversely
associated with risk of IA (hazard ratio [HR], 0.45; 95% confidence
interval [CI], 0.21-0.96; P = .04). The association was strengthened
when the definition of the outcome was limited to those positive for 2
or more autoantibodies (HR, 0.23; 95% CI, 0.09-0.58; P = .002). In the
case-cohort study, omega-3 fatty acid content of erythrocyte membranes
was also inversely associated with IA risk (HR, 0.63; 95% CI,
0.41-0.96; P = .03).

Conclusion Dietary intake of omega-3 fatty acids is associated with
reduced risk of IA in children at increased genetic risk for type 1
diabetes.

--
Ron

.

Relevant Pages

  • Re: Cholesterol Levels Are Falling, But Red Flags Are Rising
    ... > marketplace, turn out to happen to, say, .5% of all drug takers. ... produce probabilities and risk factors can ever do more than make ... time of diagnosis I had already suffered some of the typical damage ... the current diagnostic levels for diabetes. ...
    (sci.med.cardiology)
  • Omega-3 fatty-acid intake reduces the risk of islet autoimmunity in children at high risk fo
    ... Omega-3 fatty-acid intake reduces the risk of islet autoimmunity in children at high risk for diabetes ... CO - Could supplementing the diets of children at high risk for type 1 diabetes with polyunsaturated fatty acids help prevent the development of the autoimmune disease? ... A new study suggests this might indeed be possible, as researchers showed that the dietary intake of omega-3 fatty acids reduced the risk of pancreatic islet autoimmunity in children at increased risk for type 1 diabetes. ...
    (alt.support.diabetes)
  • Re: Testing in Type 2 diabetics unnecessary??? Aus study
    ... The one finding about A1c that makes it well worth lowering, and which frequently gets forgotten is this: Study after study shows a straight line relationship between A1c and the risk of a major cardiovascular event--heart attack and stroke. ... So while the likelihood of other diabetic complications might be harder to match to A1cs under 7%, that of the single most common cause of DEATH among people with diabetes is not. ... Results In adults with diabetes, the relative risk of CHD was 2.37 for the highest quintile of HbA1c level compared with the lowest after adjustment for CHD risk factors. ...
    (alt.support.diabetes)
  • Re: Type 2 Question
    ... High-Normal Fasting Blood Sugar Above 87 mg/dL Could Signal Diabetes Risk ... According to the American Diabetes Association, fasting plasma glucose (FPG) ...
    (alt.support.diabetes)
  • Re: Chris: The Actual Data about the Relationship of Tight Control & Retinopathy
    ... The UK Prospective Diabetes Study was a 20-year trial which recruited 5,102 patients with type 2 diabetes in 23 clinical centres based in England, Northern Ireland and Scotland. ... "UKPDS randomised 3867 newly diagnosed patients between a conventional blood glucose control policy, keeping fasting plasma glucose <15 mmol/l, and an intensive glucose control policy with sulphonylurea or insulin, aiming for fasting plasma glucose <6 mmol/l. ...
    (alt.support.diabetes)