Re: Anti-inflammatory Alpha-linolenic Acid Foods
- From: Taka <taka0038@xxxxxxxxx>
- Date: Tue, 30 Oct 2007 15:13:26 -0000
Supplementing with Alpha-linolenic Acid to beat the Arachidonic Acid
(AA) overload is silly ... Simply reduce the omega-6 in the diet and
you are done (takes some time and patience though). The body will
manufacture Mead acid instead of AA if it feels an "EFA deficiency".
In contrary to AA and the omega-3 derivatives, Mead acid is safe.
Playing with sesamin to inhibit delta-5 desaturation can lead to a
variety of negative health impacts from the insufficiency of the
"good" eicosanoids including e.g. (in the less serious cases) erectile
dysfunction.
Taka
Different fatty acid intakes results in different fatty acid ..
contents.
"Can displace arachidonic acid"
"The omega-3 fatty acids inhibit the conversion of linoleic acid to
arachidonic acid, thereby reducing the biosynthesis of arachidonic
acid and its eicosanoids"
"Up to 80% of the fatty acids in leafy green plants is in the form of
Alpha-linolenic Acid"
Prostaglandins Leukot Essent Fatty Acids. 1998 Mar;58(3):185-91. Links
Dietary alpha-linolenic acid increases TNF-alpha, and decreases IL-6,
IL-10 in response to LPS: effects of sesamin on the delta-5
desaturation of omega6 and omega3 fatty acids in mice.
Chavali SR, Zhong WW, Forse RA.
Department of Surgery, Harvard Institute of Medicine, Beth Israel
Deaconess Medical Center and Harvard Medical School, Boston, MA 02215,
USA.
Sesamin (a non-fat portion of sesame seed oil) inhibits delta-5
desaturase activity resulting in an accumulation of dihomo-gamma-
linolenic acid (DGLA) which can displace arachidonic acid (AA) and
decrease the formation of pro-inflammatory mediators. We investigated
the effects of consumption of diets containing 0.25wt% sesamin and 15
wt% safflower oil (SO) (providing 12% of the added fat as linoleic
acid) or a 15 wt% 2:1 mixture of linseed oil and SO (LOSO) (providing
6% alpha-linolenic acid and 6% linoleic acid) for 3 weeks on the liver
membrane fatty acid composition and on the production of prostaglandin
(PG) E2, TNF-alpha, IL-6 and IL10 in mice. Consumption of sesamin-
supplemented SO and LOSO diets resulted in a significant increase in
the levels of 20:3omega6 (DGLA), suggesting that sesamin inhibited
delta-5 desaturation of omega6 fatty acids. In animals fed LOSO diets,
the levels of alpha-linolenic acid, eicosapentaenoic acid (EPA) and of
docosahexaenoic acid (DHA) were elevated with a concomitant decrease
of arachidonic acid (AA) in the liver membrane phospholipids. Further,
in animals fed LOSO diets with or without sesamin, an increase in the
circulating levels of TNF-alpha was associated with a concomitant
decrease in PGE2. Despite a lack of differences in the levels of AA,
the PGE2 levels were significantly lower in mice fed sesamin-
supplemented SO compared to those fed SO alone. Thus, these data
suggest that irrespective of the availability of a specific fatty acid
as a substrate, through regulating the PGE2 synthesis, the production
of TNF-alpha could be modulated.
PMID: 9610840 [PubMed - indexed for MEDLINE]
---------------------------------
http://www.flaxhealth.com/foodsources.htm
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
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DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
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