Re: Butter Causes Gut Inflammation

Effects of dietary fish oil and butterfat on serum lipids and monocyte
and platelet interactions with aortic endothelial cells.

We studied effects of dietary lipids on some of the initial events in
atherogenesis. Adult swine were fed low fat/low cholesterol diets,
then challenged with a high cholesterol (1%, w/w) diet supplemented
with 11.5% (w/w) butterfat (BF) or MaxEPA fish oil (FO). Serum lipids
and monocyte and platelet adhesion to porcine aortic endothelial cells
in vitro were measured during feeding of the low fat diet and at 1, 2,
and 5 weeks after the dietary challenge. Total cholesterol increased
significantly in animals fed the BF and FO diets, but there was no
difference between the groups. Animals fed FO had total cholesterol/
high-density lipoprotein cholesterol values twice those fed BF (P less
than 0.01). After 2 weeks on the hypercholesterolemic diet, monocyte
adhesion to endothelial cells increased in swine fed FO by 123% above
those fed a low fat diet, and adhesion values remained elevated (56%
above baseline value) after 5 weeks. Monocytes from swine fed BF
showed increased adhesion by 87, 53, and 14% above those fed the low
fat diet at 1, 2, and 5 weeks respectively. Platelet adhesion to
endothelial cells decreased (P less than 0.05) after diet change and
remained low. Adhesion of platelets from swine fed FO was
significantly lower than those fed BF at 1 and cholesterol profile and
greater monocyte adhesion to endothelial cells, conditions which in
vivo may promote lesion initiation.

PMID: 2178614 [PubMed - indexed for MEDLINE]
.