Why cold weather increases risk of disease

from recent http://www.DrMirkin.com newsletter:

Does cold weather increase my risk for health
problems and diseases?

Nobody really knows why, but recent research show that
sudden drops in environmental temperature are associated with
increased risk for disease and death (American Journal of
Epidemiology, December 2008). Researchers at the University of
Athens in Greece studied people in 15 European cities. They plotted
the average temperature for that day against the number of deaths
in that city and showed that a 1 degree Centigrade decrease in
temperature from one day to the next is associated with a
1.72 percent increase in daily heart attack deaths, a 3.30 percent
increase in respiratory deaths, and a 1.25 percent increase in
stroke deaths.
This study does not tell you to move to warmer climates
because those who live in warmer cities are far more susceptible
to dying from sudden drops in temperature. This study does
suggest that you should avoid chilling and cold weather if you
suffer from heart, lung or blood vessel disease.

----------------------------

Guess what: Cold temperatures increase the amount of arachidonic acid
(AA) by stimulating the delta-5 desaturase system. And as the
educated people know, AA is the root cause of all diseases of
inflammatory nature. According to the following study carbohydrates
in the diet are needed for this effect to take place:

Lipids. 1987 Apr;22(4):282-4.

Effect of environmental temperature changes on liver delta 6 and delta
5 fatty acid desaturases depressed by hyperglycidic diet on male rats.

Losada AV, Peluffo RO.

Male rats maintained on a control diet at 24 C and shifted to 12 C for
five days showed no modification in delta 6 or delta 5 desaturase
activity. When delta 6 and delta 5 desaturase activities were
diminished by a hyperglycidic diet, shifting to cold increased both
enzymatic activities. In general, modifications observed in liver
microsomal fatty acid composition are consistent with those associated
with the enzymatic desaturation activity.
PMID: 3600205


Lipids. 1983 Jan;18(1):7-11.

Effect of environmental temperature changes on rat liver fatty acid
desaturases.

González S, Nervi AM, Peluffo RO, Brenner RR.

Female rats warm-adapted at 30-32 C for 20-25 days and then shifted to
13-15 C for 12, 24, 48, 72 and 120 hr showed that delta 9 desaturase
and fatty acid synthetase activity decay after 24 hr of cold exposure,
while delta 6 and delta 5 desaturases were increased after this period
of time. These results were confirmed by an increase of arachidonic
acid of heart and liver microsomes phosphatidylcholine and a decrease
of oleic acid. Neither NADH-cyt b5 reductase nor NADH-cyt c reductase
activity of liver microsomes were significantly affected. Male rats
warm-adapted under the same conditions and then shifted to 13-15 C for
120 hr did not show significant changes in fatty acid synthetase,
delta 9 and delta 6 desaturases and enzymes of the microsomal electron
transport chain. Therefore, the desaturase response to environmental
temperature changes could be plausibly linked to female hormones.
PMID: 6835037


You may be aware of my previous post on the seasonal variation of the
desaturase system linking increased AA to depression and violence.
Why most of all problems occur in the Autumn ? Colds, depression,
suicide, stock market crashes etc.

http://tinyurl.com/5qawv7

Taka
.

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