Re: Boron

Boron deprivation alters rat behaviour and brain mineral composition
differently when fish oil instead of safflower oil is the diet fat
source.

PRIMARY OBJECTIVE: To determine whether boron deprivation affects rat
behaviour and whether behavioural responses to boron deprivation are
modified by differing amounts of dietary long-chain omega-3 fatty
acids. RESEARCH DESIGN: Female rats were fed diets containing 0.1 mg
(9 micromol)/kg boron in a factorial arrangement with dietary
variables of supplemental boron at 0 and 3mg (278 micromol)/kg and fat
sources of 75 g/kg safflower oil or 65 g/kg fish (menhaden) oil plus
10 g/kg linoleic acid. After 6 weeks, six females per treatment were
bred. Dams and pups continued on their respective diets through
gestation, lactation and after weaning. Between ages 6 and 20 weeks,
behavioural tests were performed on 13-15 male offspring from three
dams in each dietary treatment. The rats were euthanized at age 21
weeks for the collection of tissues and blood. METHODS AND PROCEDURES:
At ages 6 and 19 weeks, auditory startle was evaluated with an
acoustic startle system and avoidance behaviour was evaluated by using
an elevated plus maze. At ages 7 and 20 weeks, spontaneous behaviour
activity was evaluated with a photobeam activity system. A brightness
discrimination test was performed on the rats between age 15 and 16
weeks. Brain mineral composition was determined by coupled argon
plasma atomic emission spectroscopy. Plasma total glutathione was
determined by HPLC and total cholesterol and 8-iso-prostaglandin
F2alpha (8-iso-PGF2alpha) were determined by using commercially
available kits. MAIN OUTCOMES AND RESULTS: Boron-deficient rats were
less active than boron-adequate rats when fed safflower oil based on
reduced number, distance and time of horizontal movements, front
entries, margin distance and vertical breaks and jumps in the
spontaneous activity evaluation. Feeding fish oil instead of safflower
oil attenuated the activity response to boron deprivation. In the plus
maze evaluation, the behavioural reactivity of the boron-deficient
rats fed fish oil was noticeably different than the other three
treatments. They made more entries into both open and closed arms and
the center area and thus visited more locations. The boron-deficient
rats fed fish oil also exhibited the lowest copper and zinc and
highest boron concentrations in brain and the highest plasma
glutathione concentration. Both boron deprivation and safflower oil
increased plasma 8-iso-PGF2alpha. CONCLUSIONS: Both dietary boron and
long-chain omega-3 fatty acids influence rat behaviour and brain
composition and the influence of one these bioactive substances can be
altered by changing the intake of the other. Brain mineral and plasma
cholesterol, glutathione and 8-iso-PGF2alpha findings suggest that rat
behaviour is affected by an interaction between boron and fish oil
because both affect oxidative metabolism and act the cellular membrane
level.

PMID: 16910176


So it seems to me that boron just counteracts dangerous AA metabolism
like the fish oil ...

Taka
.

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