Re: Help with word please

From: djgordon (danigordon_at_bellsouth.net)
Date: 02/22/05 

Date: Tue, 22 Feb 2005 00:20:54 -0600

Phenothiazines are contraindicated for patients with torsades, you'll have
to look at this list and see which one is the one you're looking for:

In the U.S.-

Chlorpromazine Hydrochloride Intensol1
Compazine8
Compazine Spansule8
Mellaril11
Mellaril Concentrate11
Mellaril-S11
Permitil2
Permitil Concentrate2
Prolixin2
Prolixin Concentrate2
Prolixin Decanoate2

 Prolixin Enanthate2
Serentil3
Serentil Concentrate3
Stelazine12
Stelazine Concentrate12
Thorazine1
Thorazine Spansule1
Trilafon6
Trilafon Concentrate6
Vesprin13

Here is the reference to go with that list:

Drug interactions with the antihistamines astemizole (recalled from US
market) and terfenadine (recalled from US market) can precipitate torsade;
these drugs should never be used with class IA, IC, or III agents.
Astemizole and terfenadine, in high dosages or when used in combination with
the azole antifungal drugs or the macrolide antibiotics, have been reported
to precipitate torsade and sudden death.
Grapefruit juice has been shown to slow the hepatic metabolism of these
antihistamines as well as other drugs and to prolong the QT interval in
patients taking astemizole or terfenadine (recently taken off the market by
the US Food and Drug Administration [FDA]).
Clinical implications of this interaction are unclear.
Other drugs that prolong the QT interval and have been implicated in cases
of torsade include phenothiazines, tricyclic antidepressants, lithium
carbonate, cisapride, Highly Active Anti-Retrovirals (HAART), high dose
methadone , anthracycline chemotherapeutic agents (eg, doxorubicin,
daunomycin), and any other medication using the CYP3A metabolic pathway.

Dani
"Susan Mitchell" <medlawtrans@comcast.net> wrote in message
news:FKCdnQS4AZZ1UIffRVn-tQ@comcast.com...
> "There is also a rare problem called torsades de pointes in which his
heart
> beats abnormally. We also discussed that this can be extreme and certain
> medications can increase the risk including the S/L thyodurazine or could
be
> cyothrozine group or furosemide. She's a tad hard to understand but not
too
> much. I can definitely hear all the thy or cy/o/dura/zine and actually
> sounds more like they thy/o/dura/zine. I know I must be a bit tired and I
> should get it but I'm not. This is a cancer patient that will be taking
> arsenic trioxide and she is listing potential problems and treatments of
> them, etc.
>
> Thanks for any assistance! Hope someone's up to see this!!
>
> --
> Sue -- Firefighter mom -- Still Rabid UW Dawg Fan!
> (to reply send to medlawtrans@comcast.net)
>
>