Re: Mitochondrial oxidative stress

From: Dr. Andrew B. Chung, MD/PhD (nospam5_at_heartmdphd.com)
Date: 06/06/04 

Date: 6 Jun 2004 15:42:11 -0700

ironjustice@aol.comdoe (doe) wrote in message news:<20040606133828.09339.00000613@mb-m03.aol.com>...
> Mech Ageing Dev. 2004 Jun;125(6):417-20. Related Articles, Links
>
>
> Mitochondrial oxidative stress can lead to nuclear hypermutability.
>
> Hartman P, Ponder R, Lo HH, Ishii N.
>
> Biology Department, Texas Christian University, Fort Worth, TX 76129, USA.
>
> Reactive oxygen species (ROS) are generated in mitochondria and are thought to
> be important in aging, carcinogenesis, and the development of other
> pathologies. We now provide direct experimental evidence linking mitochondrial
> ROS generation to the induction of nuclear DNA damage and subsequent
> mutagenesis of a chromosomal gene. Specifically, we demonstrate that the mev-1
> mutant of Caenorhabditis elegans has elevated levels of oxidative damage in its
> chromosomal DNA. This mutant was shown previously to overproduce ROS in its
> mitochondria. We also show that mutation frequencies were higher in the mev-1
> mutant under hypoxia than in the wild type strain. By extension, these data
> imply that mitochondrially derived ROS mutate other genes, including tumor
> suppressor genes and oncogenes. We propose that this three-step process
> (mitochondrial ROS --> nuclear DNA damage --> mutation) contributes to aging
> and age-associated diseases.
>
> PMID: 15178131 [PubMed - in process]
>
> --------------------------------------------------------------------------
> ------
>
> Who loves ya.
> Tom

Appreciate the citation.

This is actually relevant to the discussions in SMC, ASD, and MHD
about the 2PD approach and so these groups have been added to this
thread.

How so?

The more you eat (in excess of 2 pounds per day)... the more
mitochondrial ROS there will be necessarily generated (we have long
known that we can double the lifespan of mammals by restricting their
food intake).

A few words to the wise...

Servant to the humblest person in the universe,

Andrew 

--
Dr. Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
http://www.heartmdphd.com/
**
Who is the humblest person in the universe?
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Relevant Pages

  • Mitochondrial oxidative stress
    ... Mitochondrial oxidative stress can lead to nuclear hypermutability. ... Reactive oxygen species (ROS) are generated in mitochondria and are thought to ...
    (sci.med)
  • Re: Mitochondrial oxidative stress
    ... > for some background information about cell biology and mitochondria. ... "Mitochondria are the sites of aerobic respiration and generally are the major energy ... It is the inner one that is one of the most impermeable membranes in the known universe. ... Dr. Andrew B. Chung, MD/PhD ...
    (sci.med)
  • Re: Mitochondrial oxidative stress
    ... Dr. Andrew B. Chung, MD/PhD wrote: ... >>Mitochondrial oxidative stress can lead to nuclear hypermutability. ... >>Reactive oxygen species (ROS) are generated in mitochondria and are thought to ...
    (sci.med)
  • Re: Mitochondrial oxidative stress
    ... Might it not be even more relevant to statin adverse effects? ... The mitochondrial damage proven in the IMPOSTER trial, ... >> ROS generation to the induction of nuclear DNA damage and subsequent ... >> mitochondria. ...
    (sci.med)