Re: Mitochondrial oxidative stress

From: Sharon Hope (shope_at_anet.net)
Date: 06/07/04 

Date: Mon, 07 Jun 2004 00:20:55 GMT

Might it not be even more relevant to statin adverse effects?

The mitochondrial damage proven in the IMPOSTER trial, as well as all the
evidence of myopathy and myositis, directly impacts the oxygen interchange
at the cell level.

If, as the quote indicates, this leads to actual mutation, it could help
explain why patients suffering statin damage continue to exhibit symptoms
long after ceasing to take the statin drug.

"Dr. Andrew B. Chung, MD/PhD" <nospam5@heartmdphd.com> wrote in message
news:9fcab6f7.0406061442.10616224@posting.google.com...
> ironjustice@aol.comdoe (doe) wrote in message
news:<20040606133828.09339.00000613@mb-m03.aol.com>...
> > Mech Ageing Dev. 2004 Jun;125(6):417-20. Related Articles, Links
> >
> >
> > Mitochondrial oxidative stress can lead to nuclear hypermutability.
> >
> > Hartman P, Ponder R, Lo HH, Ishii N.
> >
> > Biology Department, Texas Christian University, Fort Worth, TX 76129,
USA.
> >
> > Reactive oxygen species (ROS) are generated in mitochondria and are
thought to
> > be important in aging, carcinogenesis, and the development of other
> > pathologies. We now provide direct experimental evidence linking
mitochondrial
> > ROS generation to the induction of nuclear DNA damage and subsequent
> > mutagenesis of a chromosomal gene. Specifically, we demonstrate that the
mev-1
> > mutant of Caenorhabditis elegans has elevated levels of oxidative damage
in its
> > chromosomal DNA. This mutant was shown previously to overproduce ROS in
its
> > mitochondria. We also show that mutation frequencies were higher in the
mev-1
> > mutant under hypoxia than in the wild type strain. By extension, these
data
> > imply that mitochondrially derived ROS mutate other genes, including
tumor
> > suppressor genes and oncogenes. We propose that this three-step process
> > (mitochondrial ROS --> nuclear DNA damage --> mutation) contributes to
aging
> > and age-associated diseases.
> >
> > PMID: 15178131 [PubMed - in process]
> >
>
> --------------------------------------------------------------------------
> > ------
> >
> > Who loves ya.
> > Tom
>
> Appreciate the citation.
>
> This is actually relevant to the discussions in SMC, ASD, and MHD
> about the 2PD approach and so these groups have been added to this
> thread.
>
> How so?
>
> The more you eat (in excess of 2 pounds per day)... the more
> mitochondrial ROS there will be necessarily generated (we have long
> known that we can double the lifespan of mammals by restricting their
> food intake).
>
> A few words to the wise...
>
> Servant to the humblest person in the universe,
>
> Andrew
>
> --
> Dr. Andrew B. Chung, MD/PhD
> Board-Certified Cardiologist
> http://www.heartmdphd.com/
>
> **
> Who is the humblest person in the universe?
> http://makeashorterlink.com/?L26062048
>
> What is all this about?
> http://makeashorterlink.com/?R20632B48
>
> Is this spam?
> http://makeashorterlink.com/?N69721867

Relevant Pages

  • Toxicology - How statins cause cell death: Statins induce calcium-dependent mitochondrial pe
    ... Toxicologists are discovering how statins cause cell death - which is ... The February issue shows how statins cause mitochondrial damage that leads ... liver mitochondria isolated from hypercholesterolemic LDL receptor knockout ...
    (sci.med.cardiology)
  • Re: Dietary Fats Modulate Oxidative Stess
    ... Oxidative damage to mitochondrial DNA is inversely related to maximum ... DNA damage is considered of paramount importance in aging. ... oxidatively damage mtDNA in a way related to the aging rate of each ... mitochondria with intact DNA. ...
    (sci.med.nutrition)
  • Statins, mitochondria, chronic disease and aging
    ... STATINS, MITOCHONDRIA, CHRONIC DISEASE AND AGING ... tendency for congestive heart failure in statin drug users. ... supplemental ubiquinone or substantial reductions in statin dosage. ... vital to mitochondrial function.and energy production. ...
    (sci.med.cardiology)
  • Re: Mitochondrial oxidative stress
    ... Dr. Andrew B. Chung, MD/PhD wrote: ... >>Mitochondrial oxidative stress can lead to nuclear hypermutability. ... >>Reactive oxygen species (ROS) are generated in mitochondria and are thought to ...
    (sci.med)
  • Re: Mitochondrial oxidative stress
    ... > Mitochondrial oxidative stress can lead to nuclear hypermutability. ... > Reactive oxygen species (ROS) are generated in mitochondria and are thought to ... Servant to the humblest person in the universe, ...
    (sci.med)