mega dose viitamins slow the progression of T1 Diabetes Mellitus
From: William A. Noyes (no.address_at_ctc.net)
Date: 06/07/04
- Next message: MD: "E124 Ponceau 4R; Cochineal Red A"
- Previous message: Dr. Andrew B. Chung, MD/PhD: "Re: Mitochondrial oxidative stress"
- Next in thread: William A. Noyes: "Re: mega dose viitamins slow the progression of T1 Diabetes Mellitus"
- Reply: William A. Noyes: "Re: mega dose viitamins slow the progression of T1 Diabetes Mellitus"
- Messages sorted by: [ date ] [ thread ]
Date: Mon, 7 Jun 2004 00:33:26 -0700
Abstract and then comments.
Eur J Endocrinol. 2004 May;150(5):719-24. Related Articles, Links
A randomized trial of nicotinamide and vitamin E in children with
recent onset type 1 diabetes (IMDIAB IX).
Crino A, Schiaffini R, Manfrini S, Mesturino C, Visalli N, Anguissola
GB, Suraci C, Pitocco D, Spera S, Corbi S, Matteoli MC, Patera IP,
Manca Bitti ML, Bizzarri C, Pozzilli P; On behalf of the IMDIAB group.
Ospedale Bambino Gesu, Piazza S. Onofrio 4, 00163 Roma, Italy.
OBJECTIVE: Various adjuvant therapies have been introduced along with
intensive insulin therapy in patients with recent onset type 1
diabetes. Nicotinamide (NA), administered at diagnosis of the disease,
can have beneficial effects on the clinical remission rate, improve
metabolic control and preserve or slightly increase beta-cell
function, probably by reducing toxicity due to free oxygen radicals.
Vitamin E, a known antioxidant, inhibits lipid peroxidation; this can
lead to protection of islet beta cells from the combined effects of
interleukin 1, tumor necrosis factor and gamma interferon. The aim of
the present study was to investigate whether the addition of vitamin E
to NA could improve metabolic control and the residual beta-cell
function, as measured by C-peptide secretion, in children and
adolescents with recent onset type 1 diabetes; patients were
followed-up for 2 years after diagnosis. PATIENTS AND STUDY DESIGN:
Recent onset type 1 diabetes patients (n=64, mean age 8.8 years) were
recruited by participating centres of the IMDIAB group. Thirty-two
patients were randomized to NA (25 mg/kg body weight) plus vitamin E
(15 mg/kg body weight); 32 patients acted as controls and received NA
only at the same dose as above. Intensive insulin therapy was applied
to both treatment groups. RESULTS: There were three drop outs during
the 2-year follow-up period. Overall, patients assigned to the
NA+vitamin E group or the NA group did not significantly differ in
terms of glycated hemoglobin (HbA1c) levels, insulin requirement or
baseline C-peptide secretion. Patients diagnosed at an age of less
than 9 years showed significantly reduced C-peptide levels compared
with those aged over 9 years at diagnosis and at the 2-year follow-up
but there were no differences between the NA and NA+vitamin E treated
groups. However at 6 months, patients over 9 years of age treated with
NA+vitamin E showed significantly higher C-peptide compared with the
NA group (P<0.003). In both age groups and in the different treatment
groups, C-peptide levels found at diagnosis were preserved 2 years
later. CONCLUSIONS: The use of NA alone, or in combination with
vitamin E, along with intensive insulin therapy is able to preserve
baseline C-peptide secretion for up to 2 years after diagnosis. This
finding is of particular interest for pre-pubertal children with type
1 diabetes and has never been reported before.
PMID: 15132730 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
ds=4260677&dopt=Abstract
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
ds=9437658&dopt=Abstract
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
ds=12519385&dopt=Abstract
First, an explanation for those who don't
know significance of C-peptide.
"All insulins are composed of A and B
peptide chains linked by disulfides bonds.
They are cleaved from proinsulins and two
dipeptides via reactions that liberate a connecting
C peptide and two peptides as well as the active hormone.
Proinsulins are stored in secretory granules,..........
..........Circulating C peptide concentrations provide
a measure of endogenous insulin production in
individuals treated with hormones from other
sources (since preparations from other animals do not
contain it); but C-peptides have longer half-lives. Humans
have only one insulin type,...................."
Dictionary of Endocrinology & Related Biomedical Sciences
Hence, the higher levels of the nicotinamide and vitamin E
is more effective than just nicotinamide and much more
effective than doing nothing because the higher C-peptides
levels present in the vitamin combination indicate higher
levels of native insulin production.
Clearly even if the combination of nicotinamide and
vitamin E only slows the progress of T1 diabetes it
is still worth doing. If it only slows the onset by two
years, it is quite reasonable to assume that
this will add two years to the lifespan of T1 diabetics.
The T1 diabetics from the class of "67" are now in
deep trouble with DM complications. This represents
a loss for both the individuals and the larger society.
The use of this vitamin combination is something
the should be implemented now not later after
decades of more stalling by medical community
stick in the muds.
Mega-dose vitamins have their uses.......
................................. William A. Noyes
Thank to Tim for posting this abstract earlier.
- Next message: MD: "E124 Ponceau 4R; Cochineal Red A"
- Previous message: Dr. Andrew B. Chung, MD/PhD: "Re: Mitochondrial oxidative stress"
- Next in thread: William A. Noyes: "Re: mega dose viitamins slow the progression of T1 Diabetes Mellitus"
- Reply: William A. Noyes: "Re: mega dose viitamins slow the progression of T1 Diabetes Mellitus"
- Messages sorted by: [ date ] [ thread ]
Relevant Pages
|
